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L0879

Sigma-Aldrich

Leu-Leu-Leu

≥90% (elemental analysis), suitable for mass spectrometry (MS)

Synonym(s):

Trileucine

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About This Item

Empirical Formula (Hill Notation):
C18H35N3O4
CAS Number:
10329-75-6
Molecular Weight:
357.49
MDL number:
MFCD00038309
UNSPSC Code:
12352202
PubChem Substance ID:
24896267
NACRES:
NA.26
Pricing and availability is not currently available.

Product Name

Leu-Leu-Leu, ≥90% (elemental analysis)

assay

≥90% (elemental analysis)

form

powder

technique(s)

electron microscopy: suitable
mass spectrometry (MS): suitable

color

white

storage temp.

−20°C

SMILES string

CC(C)CC(N)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(O)=O

InChI

1S/C18H35N3O4/c1-10(2)7-13(19)16(22)20-14(8-11(3)4)17(23)21-15(18(24)25)9-12(5)6/h10-15H,7-9,19H2,1-6H3,(H,20,22)(H,21,23)(H,24,25)

InChI key

DNDWZFHLZVYOGF-UHFFFAOYSA-N

Related Categories

Amino Acid Sequence

Leu-Leu-Leu

Application

Trileucine (Leu-Leu-Leu), an endosome escape moiety, may be used for pH-dependent endosomal membrane disruption to release agents such as antisense oligonucleotides (AONs) inside cells. Trileucine is used to evaluate the absorption characteristics of reversed phase liquid chromatography (HPLC) media.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCL3876
BCCG6451
BCCC5080
BCBV1900
BCBT1427

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K L Strauch et al.
Journal of bacteriology, 156(2), 743-751 (1983-11-01)
Pseudorevertants able to use L-leucyl-L-leucyl-L-leucine as a leucine source have been isolated from a Salmonella typhimurium strain carrying stable (nonreverting) mutations in pepN, pepA, and pepB. These strains carry mutations at a locus pto (peptidase T overproducer) tightly linked to
David Lechuga-Ballesteros et al.
Journal of pharmaceutical sciences, 97(1), 287-302 (2007-09-08)
For particles to be useful medicinal aerosols, not only their aerodynamic diameter has to be on the order of a few micrometers but also they have to be chemically and physically stable. Manufacture of respirable particles is a technical challenge
J Kolstad et al.
The Journal of applied bacteriology, 58(5), 449-455 (1985-05-01)
Solubilized cell walls of group N streptococci contain two electrophoretically distinct peptidases, one of which hydrolysed trileucine only, while the second hydrolysed a wide range of di- and tripeptides. Neither enzyme possessed leucine aminopeptidase or endopeptidase activity. Four and three
S A Adibi et al.
Metabolism: clinical and experimental, 32(2), 103-105 (1983-02-01)
When baboons, while consuming an adequate diet, were infused continuously for 3 days with parenteral solutions (1I/day) containing either triglycine (50 mM) or trileucine (5 mM) there was either no or very little accumulation of these peptides either in plasma
K Go et al.
Biopolymers, 36(5), 607-614 (1995-11-01)
In order to test the helical preference of short oligo-L-leucines, we crystallized the tripeptide L-leucyl-L-leucyl-L-leucine (LLL) and carried out x-ray diffraction studies of it (L-leucyl-L-leucyl-Lleucine)2. 3CH3OH. H2O, (C39H84N6O12), crystallized in the monoclinic system, space group P2(1), cell parameters: a =
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