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G0419

Sigma-Aldrich

GR 55562 dihydrobromide

>97% (HPLC), powder

Synonym(s):

3-[3-(Dimethylamino)propyl]-4-hydroxy-N-[4-(4-pyridinyl)phenyl]benzamide dihydrobromide

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About This Item

Empirical Formula (Hill Notation):
C23H25N3O2 · 2HBr
CAS Number:
172854-55-6
Molecular Weight:
537.29
MDL number:
MFCD06201848
UNSPSC Code:
12352202

description

Store tightly sealed with desiccant.

assay

>97% (HPLC)

form

powder

color

light yellow

solubility

H2O: ~12 mg/mL (with mixing)

Storage temp.

2-8°C

InChI

1S/C23H25N3O2.ClH/c1-26(2)15-3-4-19-16-20(7-10-22(19)27)23(28)25-21-8-5-17(6-9-21)18-11-13-24-14-12-18;/h5-14,16,27H,3-4,15H2,1-2H3,(H,25,28);1H

Inchi Key

NUDSRNNZTVHCKY-UHFFFAOYSA-N

Biochem/physiol Actions

5-HT1B/5-HT1D serotonin receptor antagonist

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes under agreement from Glaxo­Smith­Kline

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
093K4623

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M R MacLean et al.
British journal of pharmacology, 119(2), 277-282 (1996-09-01)
1. The 5-hydroxytryptamine (5-HT) receptors mediating contraction of human isolated pulmonary artery rings were investigated. Responses to the agonists 5-carboximidotryptamine (5-CT, non-selective 5-HT1 agonist), sumatriptan (5-HT1D-like receptor agonist), 5-HT and 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT, 5-HT1A receptor agonist) were studied. Responses to 5-HT
Ji-Hyun Kim et al.
Pharmacology, biochemistry, and behavior, 87(1), 41-47 (2007-05-05)
The present study was undertaken to investigate the antidepressant-like effects of the methylene chloride fraction of Albizzia julibrissin (MCAJ) using a tail suspension test in mice. MCAJ was orally administered at 50, 100, or 200 mg/kg to mice, 1 h
E Przegaliński et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 53(3), 383-394 (2002-10-09)
The present study was designed to examine the effect of 5-HT1B receptor ligands microinjected into the subregions of the nucleus accumbens (the shell and the core) on the locomotor hyperactivity induced by cocaine in rats. Male Wistar rats were implanted
M Filip et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 52(2), 249-263 (2001-07-17)
Mesolimbic dopamine pathways play a critical role in the behavioural effects of cocaine in rodents. Nonetheless, research has also demonstrated involvement of 5-hydroxytryptamine (5-HT; serotonin) transmission in these effects. The present study investigated the ability of selective 5-HT1B receptor ligands
Edmund Przegaliński et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 12(5), 387-396 (2002-09-05)
The present study was designed to find out whether 5-HT(1B) receptors located in subareas of the nucleus accumbens played a role in cocaine sensitization in rats, and whether pharmacological activation of these receptors could modify this drug effect. Male Wistar
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