E5627
Erythropoietin human
recombinant, expressed in CHO cells, lyophilized powder, suitable for cell culture, ~100,000 units/mg protein
Synonym(s):
EPO
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About This Item
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biological source
human
Quality Level
recombinant
expressed in CHO cells
form
lyophilized powder
specific activity
~100,000 units/mg protein
packaging
pkg of 10UN
technique(s)
cell culture | mammalian: suitable
color
white
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... EPO(2056) , EPOR(2057)
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General description
Erythropoietin is a glycoprotein cytokine and hormone and belongs to the type I cytokine superfamily. It undergoes posttranslational modifications and exists as 18 and 30 kDa molecular weight forms. It is mapped to human chromosome 7q22.[1]
Application
Biochem/physiol Actions
Erythropoietin (EPO) elicits antiapoptotic, anti-inflammatory and tissue protective functions.[5] EPO is essential for maintaining red blood progenitor cells. It is used for treating hematological disorders and in perioperative therapies.[6] A homozygous mutation in EPO gene obstructs its interaction with receptor and the signaling cascade resulting in severe anemia.[7] Elevated levels of EPO due to mutations is implicated in the pathogenesis of familial erythrocytosis.[8]
Erythropoietin is a glycoprotein that is the principal regulator of red blood cell growth and differentiation.
Physical form
Lyophilized as 10 units EPO, 10 mg trisodium citrate and 10 mg NaCl at pH ≅7.0.
Analysis Note
The biological activity is assayed in tissue culture using mouse fetal liver cells.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Erythropoietin use and abuse
John MJ, et al.
Indian Journal of Endocrinology and Metabolism, 16(2), 220-220 (2012)
Erythropoietin Protects Against Cognitive Impairment and Hippocampal Neurodegeneration in Diabetic Mice
Othman M, et al.
Behavioral Sciences, 9(1), 4-4 (2019)
Recombinant erythropoietin in clinical practice
Ng T, et al.
Postgraduate Medical Journal, 79(933), 367-376 (2003)
Functional selectivity in cytokine signaling revealed through a pathogenic EPO mutation
Kim AR, et al.
Cell, 168(6), 1053-1064 (2017)
Erythropoietin decreases the excitatory neurotransmitter release probability and enhances synaptic plasticity in mice hippocampal slices
Kamal A, et al.
Brain Research, 1410, 33-37 (2011)
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