Skip to Content
MilliporeSigma
All Photos(1)

Documents

C8863

Sigma-Aldrich

7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3‑d]pyrimidin-4-ylamine

≥98% (HPLC)

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C23H22N4O
CAS Number:
213743-31-8
Molecular Weight:
370.45
MDL number:
MFCD04974490
UNSPSC Code:
12352116
PubChem Substance ID:
24278409
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

color

white

solubility

DMSO: soluble 17 mg/mL at ≤60 °C

storage temp.

2-8°C

SMILES string

Nc1ncnc2n(cc(-c3ccc(Oc4ccccc4)cc3)c12)C5CCCC5

InChI

1S/C23H22N4O/c24-22-21-20(14-27(17-6-4-5-7-17)23(21)26-15-25-22)16-10-12-19(13-11-16)28-18-8-2-1-3-9-18/h1-3,8-15,17H,4-7H2,(H2,24,25,26)

InChI key

FMETVQKSDIOGPX-UHFFFAOYSA-N

Gene Information

human ... KDR(3791) , LCK(3932) , TEK(7010)

Biochem/physiol Actions

A potent and selective pyrrolo[2,3-d]pyrimidine Lck inhibitor.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Susana Rosa et al.
Current protocols in stem cell biology, 50(1), e93-e93 (2019-09-04)
This article describes a screening platform to identify compounds that affect human embryonic vascular development. The procedure comprises the generation of human embryonic-like endothelial cells (ECs) from human pluripotent stem cells (hPSCs) and subsequent maturation under arterial flow conditions; the
Bebhinn Treanor et al.
The Journal of cell biology, 174(1), 153-161 (2006-06-28)
We report the supramolecular organization of killer Ig-like receptor (KIR) phosphorylation using a technique applicable to imaging phosphorylation of any green fluorescent protein-tagged receptor at an intercellular contact or immune synapse. Specifically, we use fluorescence lifetime imaging (FLIM) to report
Jorge Luis Galeano Niño et al.
Journal of cell science, 133(5) (2020-02-12)
It has become increasingly evident that T cell functions are subject to translational control in addition to transcriptional regulation. Here, by using live imaging of CD8+ T cells isolated from the Lifeact-EGFP mouse, we show that T cells exhibit a

Articles

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service