A2786

Adenine

BioReagent, suitable for cell culture

• Synonym(s): 6-Aminopurine, Vitamin B₄
• Empirical Formula (Hill Notation): C₅H₅N₅
• CAS Number: 73-24-5
• Molecular Weight: 135.13
• Beilstein/REAXYS Number: 5777
• EC Number: 200-796-1
• MDL number: MFCD00041790
• UNSPSC Code: 12352205
• PubChem Substance ID: 24890691
• NACRES: NA.75

Properties

• biological source: synthetic
• product line: BioReagent
• assay: ≥99%
• form: powder
• mol wt: M_w 135.13 g/mol
• technique(s): cell culture | mammalian: suitable
• color: white to off-white
• mp: >360 °C (lit.)
• solubility: 0.5 M HCl: soluble 20 mg/mL, clear to slightly hazy, colorless to faintly yellow
• storage temp.: room temp
• SMILES string: Nc1ncnc2[nH]cnc12
• InChI: 1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10)
• InChI key: GFFGJBXGBJISGV-UHFFFAOYSA-N
• Gene Information: human ... AKT1(207) , GSK3B(2932) , LCK(3932) , MAP3K1(4214) , MAPK14(1432) , MAPK8(5599) , MAPK9(5601) , MAPKAPK2(9261) , PRKACA(5566) , PRKCA(5578) , RAF1(5894) , ROCK2(9475) ; mouse ... Mapk1(26413) ; rat ... Camk2a(25400) , Mapk10(25272)

Description

General description

Adenine is a purine nucleobase, synthesized from inosine monophosphate(IMP). It is a nitrogenous heterocyclic aromatic compound.

Application

Adenine has been used:

• a component of green medium used for the derivation of keratinocytes from plucked hair follicles
• for the serial culture of adult murine keratinocytes
• as a media component for SSEA4⁺ limbal stromal stem cell differentiation

Biochem/physiol Actions

Adenine is a component of important biomolecules such as adenosine triphosphate (ATP), nicotinamide adenine dinucleotide (NAD) and flavin adenine dinucleotide (FAD). NAD and FAD forms the structure of DNA and RNA, and plays important role in protein synthesis. ATP is an energy source, that is essential for cellular respiration.

Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 3
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves