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PHR1767

Supelco

Melatonin

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Melatonin, N-Acetyl-5-methoxytryptamine

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500 MG
$166.00

$166.00

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500 MG
$166.00

About This Item

Empirical Formula (Hill Notation):
C13H16N2O2
CAS Number:
73-31-4
Molecular Weight:
232.28
Beilstein/REAXYS Number:
205542
EC Number:
200-797-7
MDL number:
MFCD00005655
UNSPSC Code:
41116107
PubChem Substance ID:
329823599
NACRES:
NA.24

$166.00

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grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

agency

traceable to BP 1077
traceable to USP 1380105

API family

melatonin

form

solid

CofA

current certificate can be downloaded

packaging

pkg of 500 mg

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

116.5-118 °C (lit.)

application(s)

pharmaceutical (small molecule)

storage temp.

2-8°C

SMILES string

COc1ccc2[nH]cc(CCNC(C)=O)c2c1

InChI

1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16)

InChI key

DRLFMBDRBRZALE-UHFFFAOYSA-N

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General description

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. It is analyzed using GMP validated instruments as per pharmacopeia monograph methods and is traceable to Unites States Pharmacopeia (USP), European Pharmacopeia (EP), and British Pharmacopeia (BP) primary standards, wherever applicable. It is provided with a comprehensive certificate of analysis (CoA) containing a certified purity value, calculated by the mass balance approach.
All information regarding the use of this CRM can be found on the certificate of analysis.

Melatonin is a methoxyindole compound secreted by the pineal gland in the mammalian brain. It regulates the sleep-wake cycles (circadian rhythm) and also has anti-inflammatory and antioxidant properties.

Application

Melatonin pharmaceutical reference standard may also be used as follows:
  • Development and validation of a high-performance liquid chromatography (HPLC) method combined with UV detection to determine melatonin in capsule dosage forms
  • Determination of melatonin in dog plasma samples by liquid chromatography-tandem mass spectrometry (LC-MS/MS) method
  • Simultaneous electrochemical analysis of melatonin and 5-hydroxytryptophan by poly-(melamine)/poly-(o-aminophenol) modified screen printed electrodes (SPCs) in human urine samples
  • Determination of melatonin in pharmaceutical formulations by voltammetric and amperometric methods using carbon black modified glassy carbon electrode
  • Electroanalytical determination of melatonin in tablet and human urine samples using a boron-doped diamond electrode and square-wave voltammetry (SWV)
  • Development of nanopalladium polymeric nanocomposite modified glassy carbon electrode (GCE) for qualitative and quantitative analyses of melatonin in tablets and human urine samples by square-wave voltammetry
  • Liquid chromatography-diode array detection (LC-DAD) of melatonin dose in supplements and also detection of impurities present in supplements by ultra-high-performance liquid chromatography-orbitrap mass spectrometry (UHPLC-orbitrap-MS)

Other Notes

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA8251 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Questions

  1. Em quais veículos é possível fazer a solubilização da Melatonina pra uso experimental em ratos machos wistar, utilizando a via I.P. ?

    1 answer

    1. This product is a Certified Reference Material (CRM) used as a pharmaceutical reference standard for qualitative and quantitative analyses of melatonin. Its experimental use in male Wistar rats has not been validated. An possible alternative is product M5250: https://www.sigmaaldrich.com/product/sigma/m5250.

      However, the product is not qualified for use in vivo. Suitability must be determined by the end user.

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