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36754

Sigma-Aldrich

9,11-Dideoxy-11α,9α-epoxymethanoprostaglandin F2α

~99% (TLC), 10 mg/mL in methyl acetate

Synonym(s):

U-46619, U46619

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About This Item

Empirical Formula (Hill Notation):
C21H34O4
CAS Number:
56985-40-1
Molecular Weight:
350.49
Beilstein/REAXYS Number:
4267334
MDL number:
MFCD00135238
UNSPSC Code:
12352200

assay

~99% (TLC)

concentration

10 mg/mL in methyl acetate

shipped in

dry ice

storage temp.

−20°C

SMILES string

CCCCC[C@H](O)\C=C\[C@H]1C2CC(CO2)[C@@H]1C\C=C/CCCC(O)=O

InChI

1S/C21H34O4/c1-2-3-6-9-17(22)12-13-19-18(16-14-20(19)25-15-16)10-7-4-5-8-11-21(23)24/h4,7,12-13,16-20,22H,2-3,5-6,8-11,14-15H2,1H3,(H,23,24)/b7-4-,13-12+/t16?,17-,18-,19+,20?/m0/s1

InChI key

LQANGKSBLPMBTJ-REGKDVDGSA-N

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pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

target_organs

Central nervous system

supp_hazards

EUH066

Storage Class

3 - Flammable liquids

wgk_germany

WGK 2

flash_point_f

14.0 °F

flash_point_c

-10 °C

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Matthew A Sparks et al.
Hypertension (Dallas, Tex. : 1979), 61(1), 166-173 (2012-11-15)
The prostanoid thromboxane A2 has been implicated to contribute to the pathogenesis of many cardiovascular diseases, including hypertension. To study the role of vascular thromboxane-prostanoid (TP) receptors in blood pressure regulation, we generated mice with cell-specific deletion of TP receptors
Nitin Puri et al.
Antioxidants & redox signaling, 18(5), 471-480 (2012-08-08)
Hydrogen peroxide (H(2)O(2)), a nonradical oxidant, is employed to ascertain the role of redox mechanisms in regulation of vascular tone. Where both dilation and constriction have been reported, we examined the hypothesis that the ability of H(2)O(2) to effect vasoconstriction
C E Hayward et al.
Placenta, 34(3), 281-287 (2013-01-31)
To characterise Chorionic Plate Artery (CPA) function in maternal obesity, and investigate whether leptin exposure reproduces the obese CPA phenotype in normal-BMI women. CPA responses to the thromboxane-A(2) mimetic U46619 (pre/post leptin incubation), to the nitric oxide donor sodium nitroprusside
Bin Liu et al.
American journal of physiology. Renal physiology, 305(9), F1315-F1322 (2013-08-30)
This study was to determine whether prostacyclin [prostaglandin I2 (PGI2)] evokes mouse renal vasoconstriction and, if so, the underlying mechanism(s) and how its synthesis via cyclooxygenase-1 (COX-1) influences local vasomotor reaction. Experiments were performed on vessels from C57BL/6 mice and/or
Christian A Plass et al.
Lasers in surgery and medicine, 44(9), 705-711 (2012-09-26)
As low-level laser irradiation (LLLI) seems to induce vasodilation besides many other known biological effects, LLLI has been increasingly used in therapy of medical conditions with various irradiation parameters. The aim of this study was to investigate the effect of
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