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21780

Sigma-Aldrich

Lithium carbamoylphosphate dibasic hydrate

~85% (enzymatic)

Synonym(s):

CAP-Li2, Carbamoylphosphate dilithium salt, Carbamyl phosphate dilithium salt, Carbamyl phosphoric acid dilithium salt

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About This Item

Linear Formula:
NH2COOPO3Li2·xH2O
CAS Number:
1866-68-8
Molecular Weight:
152.89 (anhydrous basis)
Beilstein/REAXYS Number:
6128395
EC Number:
217-480-4
MDL number:
MFCD00038144
UNSPSC Code:
12352200

assay

~85% (enzymatic)

storage temp.

2-8°C

SMILES string

[Li+].[Li+].NC(=O)OP([O-])([O-])=O

InChI

1S/CH4NO5P.2Li/c2-1(3)7-8(4,5)6;;/h(H2,2,3)(H2,4,5,6);;/q;2*+1/p-2

InChI key

TUHZSMCNIUXAIJ-UHFFFAOYSA-L

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Other Notes

Inhibits the carbonic anhydrase isoenzymes CA I, CA II and CA III[1]; Erythrocyte anti sickling agent[2]; Substrate for ornithine carbamoyl-transferase[3][4]

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L M Kraus et al.
Biochimica et biophysica acta, 491(2), 497-502 (1977-04-25)
The effect of oral administration of dilithium carbamyl phosphate on adult beagle dogs is dose related. The levels of carbamylation as mol valine hydantoin/mol hemoglobin tetramer reaches a plateau of 0.3-0.38 with daily doses of 100 mg/kg body weight. Related
Study of carbamyl phosphate-ornithine transcarbamylase.
G H BURNETT et al.
The Journal of biological chemistry, 229(1), 337-344 (1957-11-01)
N D Carter et al.
FEBS letters, 165(2), 197-200 (1984-01-09)
Carbamoyl phosphate has been shown to inhibit carbonic anhydrase (CA) isozymes CA I, CA II and CA III. This physiologically important molecule is the most potent, naturally occurring inhibitor of carbonic anhydrase yet found. It is also unique, among carbonic
Studies on the mechanism of action of carbamate kinase.
S GRISOLIA et al.
Biochimica et biophysica acta, 62, 293-299 (1962-08-13)

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