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Key Documents

ABS504

Sigma-Aldrich

Anti-LTBP1 Antibody hinge region

from rabbit, purified by affinity chromatography

Synonym(s):

Latent-transforming growth factor beta-binding protein 1, LTBP-1, Transforming growth factor beta-1-binding protein 1, TGF-beta-1-BP-1, Transforming growth factor beta-1-masking protein large subunit

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100 μG
$457.00

$457.00


Estimated to ship onMarch 19, 2025


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100 μG
$457.00

About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

$457.00


Estimated to ship onMarch 19, 2025


Request a Bulk Order

biological source

rabbit

Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

mouse, rat

technique(s)

immunocytochemistry: suitable
western blot: suitable

NCBI accession no.

UniProt accession no.

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This Item
ABS502SAB1305410SAB2501771
Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

antibody form

affinity isolated antibody

antibody form

serum

antibody form

purified immunoglobulin

antibody form

affinity isolated antibody

shipped in

wet ice

shipped in

dry ice

shipped in

wet ice

shipped in

wet ice

UniProt accession no.

Q00918

UniProt accession no.

Q14766

UniProt accession no.

Q14766

UniProt accession no.

P36897

Gene Information

mouse ... Ltbp1(268977)

Gene Information

human ... LTBP1(4052)

Gene Information

human ... LTBP1(4052)

Gene Information

human ... TGFBR1(7046)

General description

Latent-transforming growth factor beta-binding protein 1 (LTBP-1) is also called Transforming growth factor beta-1-binding protein 1 (TGF-beta1-BP-1). A large latent complex of TGFB1 from platelets is composed of the TGFB1 molecule non-covalently associated with a disulfide-bonded complex of a dimer of the N-terminal propeptide of the TGFB1 precursor and LTBP1. LTBP1 does not bind directly to active TGFB1 only to proforms. LTBP1 appears to be involved in the secretion of TGFB1 to sites at which it is stored or activated, and it is critical in controlling the action of TGFB1. LTBP1 may also play a role in extracellular matrix building and calcium binding mediated signaling surrounding TGFB1 activated signaling pathways. Also, because of its critical role in TGFB1 metabolism, LTBP1 is an important player in many developmental processes including embryo implantation and growth. LTBP1 is also a player in at least two distinct breast cancer metastasis signatures and has both a long and short isoform that work to establish and maintain the spatial restriction of TGFbeta bioavailability during development of many tissues including mammary development.

Immunogen

Linear peptide corresponding to rat LTBP1 hinge region.

Application

Immunocytochemistry Analysis: A representative lot detected LTBP1 hinge region in rat FRC and MG63 cells (Dallas, S., et al. (2000). Journal of Bone and Mineral. 15(1):68-81).
This Anti-LTBP1 antibody is validated for use in WB, IC for the detection of LTBP1.

Quality

Evaluated by Western Blotting in NIH/3T3 cell lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected LTBP1 hinge region in 10 µg of NIH/3T3 cell lysate.

Target description

~190 kDa observed. Uncharacterized band(s) may appear in some lysates.

Other Notes

Concentration: Please refer to lot specific datasheet.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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