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Sigma-Aldrich

Q-VD-OPh, Non-O-methylated

≥90% (HPLC), liquid, Caspase inhibitor, Calbiochem®

Synonym(s):

InSolution Q-VD-OPh, Non-O-methylated, N-(2-Quinolyl)valyl-aspartyl-(2,6-difluorophenoxy)methyl Ketone

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About This Item

Empirical Formula (Hill Notation):
C26H25F2N3O6
Molecular Weight:
513.49
UNSPSC Code:
12352200
NACRES:
NA.77

product name

Q-VD-OPh, Non-O-methylated, InSolution, ≥90%, irreversible broad-spectrum inhibitor of caspases

Quality Level

100

assay

≥90% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

shipped in

wet ice

storage temp.

−20°C

General description

A cell-permeable, irreversible, broad-spectrum caspase inhibitor (IC50 = 50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively) with effective antiapoptotic properties against all major caspase-mediated cellular apoptosis pathways. Exhibits no cytotoxic effects even at extremely high concentrations. Shown to reduce ischemic brain damage and stroke-induced programmed cell death in thymus and spleen.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
caspase-1
Product does not compete with ATP.
Reversible: no
Target IC50: 50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively

Packaging

Packaged under inert gas

Warning

Toxicity: Irritant (B)

Sequence

Q-Val-Asp-CH₂-OPh

Physical form

Supplied as a 10 mM (1 mg/195 µl) solution in DMSO.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C).

Other Notes

Braun, J.S., et al. 2007. Exp. Neurol.206, 183.
Caserta, T.M., et al. 2003. Apoptosis8, 345.
Rebbaa, A., et al. 2003. Oncogene22, 2805.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

188.6 °F - closed cup - (Dimethylsulfoxide)

flash_point_c

87 °C - closed cup - (Dimethylsulfoxide)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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