495417-M

N-Oleoyl Ethanolamine

A potent inhibitor of the ceramidase found in human kidney and cerebellum.

• Synonym(s): N-Oleoyl Ethanolamine, N-2-Hydroxyethyl-9(Z)-octadecenamide, AC Inhibitor I, Acid Ceramidase Inhibitor I, OEA
• Empirical Formula (Hill Notation): C₂₀H₃₉NO₂
• CAS Number: 111-58-0
• Molecular Weight: 325.53
• MDL number: MFCD00045972
• UNSPSC Code: 12352211

Properties

• Quality Level: 100
• assay: ≥98% (TLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white
• solubility: chloroform: 5 mg/mL; ethanol: 5 mg/mL; methanol: 5 mg/mL
• storage temp.: −20°C
• SMILES string: N(CCO)C(=O)CCCCCCC\C=C/CCCCCCCC
• InChI: 1S/C20H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(23)21-18-19-22/h9-10,22H,2-8,11-19H2,1H3,(H,21,23)/b10-9-
• InChI key: BOWVQLFMWHZBEF-KTKRTIGZSA-N

Description

General description

A potent inhibitor of the ceramidase found in human kidney and cerebellum. A specific inhibitor of acid ceramidase (IC₅₀ ~ 500 µM).

A potent inhibitor of the ceramidase found in human kidney and cerebellum. Blocks the conversion of ceramide to sphingosine. A specific inhibitor of acid ceramidase (IC₅₀ ~ 500 µM).

Biochem/physiol Actions

Primary Target
Acid ceramidase

Target IC₅₀: ~ 500 µM against acid ceramidase

Warning

Toxicity: Standard Handling (A)

Other Notes

Pahan, K., et al. 1998. J. Biol. Chem. 273, 2591.
Ping, S.E., and Barrett, G.L. 1998. J. Neurosci. Res. 54, 206.
Sugita, M., et al. 1975. Biochim. Biophys. Acta398, 125.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable