P2645
Protein Kinase A Catalytic Subunit from bovine heart
≥9 units/μg protein (cyclic-AMP is not required for this activity), lyophilized (white powder to sticky mass to hard pellet)
Synonym(s):
PKA
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P2645-1000UN
$240.00
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P2645-1000UN
$240.00
About This Item
MDL number:
UNSPSC Code:
12352204
eCl@ss:
32160410
NACRES:
NA.32
Recommended Products
form
lyophilized (white powder to sticky mass to hard pellet)
Quality Level
specific activity
≥9 units/μg protein (cyclic-AMP is not required for this activity)
mol wt
40,862 Da
storage temp.
−20°C
General description
Application
Protein Kinase A (PKA) Catalytic Subunit from bovine heart has been used-
Biochem/physiol Actions
Protein Kinase A (PKA) controls the transduction of Hedgehog signaling and participates in proliferation and fate specification.[7] It phosphorylates several neurotransmitter receptors, transcription factors and constituents of various intracellular signaling pathways.[8]
Protein Kinase A catalyzes the transfer of terminal phosphate from ATP to threonine or serine residues present on various proteins. This protein is inactive in the absence of cAMP, where the catalytic and regulatory subunits are bound together. The regulatory subunit, in the presence of cAMP, binds to cAMP and releases the catalytic subunit.[9]
Packaging
Package size based on phosphorylating units
Unit Definition
Phosphorylating Activity: One unit will transfer 1.0 picomole phosphate from ATP to hydrolyzed and partially dephosphorylated casein per minute at pH 6.5 at 30°C, determined by measuring the production of ADP.
Physical form
Lyophilized powder with sucrose and phosphate buffer salts as stabilizer.
Preparation Note
Prepared from protein kinase A (P 5511)
Disclaimer
Please note that the pack size has been changed to align with the unit definition, while the number of phosphorylating units remain the same as before.
inhibitor
Product No.
Description
Pricing
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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