A potent, cell-permeable, reversible, and ATP-competitive inhibitor of cyclic-nucleotide-dependent protein kinases. Inhibits protein kinase A (Ki = 1.2 µM), myosin light chain kinase (Ki = 68 µM), protein kinase C (Ki = 15 µM), and protein kinase G (Ki = 480 nM).
A potent, cell-permeable, reversible, and ATP-competitive, and highly active inhibitor of cyclic-nucleotide-dependent protein kinases. Inhibits myosin light chain kinase (Ki = 68 µM), protein kinase A (Ki = 1.2 µM), protein kinase C (Ki = 15 µM), and protein kinase G (Ki = 480 nM).
Biochem/physiol Actions
Cell permeable: yes
Product competes with ATP.
Reversible: yes
Target Ki: 68 µM against MLCK
Warning
Toxicity: Standard Handling (A)
Preparation Note
Further dilute with aqueous buffer just prior to use.
Other Notes
Ido, M., et al. 1991. Br. J. Cancer 64, 1103. Hagiwara, M., et al. 1987. Mol. Pharmacol. 31, 523. Inagaki, M., et al. 1986. Mol. Pharmacol.29, 577. Hidaka, H., et al. 1984. Biochemistry23, 5036.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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