1.06049

Dichloromethane

EMPROVE^® ESSENTIAL, Ph. Eur., BP, NF

• Synonym(s): DCM, Methylene chloride, Methylene dichloride, Methylene chloride
• Empirical Formula (Hill Notation): CH₂Cl₂
• CAS Number: 75-09-2
• Molecular Weight: 84.93
• Beilstein/REAXYS Number: 1730800
• MDL number: MFCD00000881
• UNSPSC Code: 12191502
• EC Index Number: 200-838-9

Properties

• agency: BP; NF; Ph. Eur.
• Quality Level: 500
• vapor density: 2.9 (vs air)
• vapor pressure: 24.45 psi ( 55 °C); 6.83 psi ( 20 °C)
• product line: EMPROVE^® ESSENTIAL
• assay: ≥99% (GC)
• form: liquid
• autoignition temp.: 1223 °F; 605 °C (DIN 51794)
• expl. lim.: 22 %
• technique(s): API processing | polymorph screening: suitable
• refractive index: n20/D 1.424 (lit.)
• pH: 7 (20 °C)
• bp: 39.8-40 °C (lit.)
• mp: -95 °C; −95 °C (lit.)
• solubility: 20 g/L
• density: 1.325 g/mL at 25 °C (lit.)
• application(s): liquid formulation; pharmaceutical
• storage temp.: 2-30°C
• SMILES string: ClCCl
• InChI: 1S/CH2Cl2/c2-1-3/h1H2
• InChI key: YMWUJEATGCHHMB-UHFFFAOYSA-N

Description

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Methanol is used as solvent in a variety of pharmaceutical production processes, including tablet coating, liposome production, microsphere, and nanoparticle production.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• pictograms: GHS08,GHS07
• signalword: Warning
• hcodes: H315,H319,H336,H351
• pcodes: P202 - P261 - P264 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Central nervous system
• Storage Class: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• wgk_germany: WGK 2
• flash_point_f: does not flash
• flash_point_c: does not flash