Post-traumatic epilepsy is prevalent, often difficult to manage, and currently cannot be prevented. Although cooling is broadly neuroprotective, cooling-induced prevention of chronic spontaneous recurrent seizures has never been demonstrated. We examined the effect of mild passive focal cooling of the
Comb-shaped glycopolymer/peptide bioconjugates are constructed by grafting reduced glutathione (GSH) onto acrylate-functional block glycocopolymers via thiol-ene click chemistry. In aqueous solution, the glycopolymer/GSH bioconjugate self-assembles to sugar-installed spherical micelles. The size of micelles decreases with increasing pH, demonstrating pH-responsive character.
Chemical communications (Cambridge, England), 49(26), 2649-2651 (2013-02-22)
We present the hysteresis of the response of the poly(N-isopropylacrylamide)-co-acrylic acid microgel-based etalons to solution temperature and pH changes. We find that the optical hysteresis of the etalon can be controlled using various solution ionic strengths and/or counterions, as well
Chemical communications (Cambridge, England), 49(26), 2643-2645 (2013-02-23)
Chemi-enzymatic synthesis of ribavirin acrylate and subsequent RAFT co-polymerization with acrylic acid afforded a formulation of a broad spectrum antiviral drug which avoids accumulation in erythrocytes, the origin of the main side effect of ribavirin. In cultured macrophages the macromolecular
Green, hydrophobic device for controlled transdermal release of diclofenac sodium was designed from in situ nanosilica/acrylic acid grafted guargum membranes. Best grafting condition was assigned and nanocomposites were formed in situ using varying proportions of aqueous nanosilica sol. Nanocomposite/drug conjugates
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.