291587

Sodium amide

50 wt. % suspension in toluene

• Linear Formula: NaNH₂
• CAS Number: 7782-92-5
• Molecular Weight: 39.01
• MDL number: MFCD00011117
• UNSPSC Code: 12352301
• PubChem Substance ID: 24857541
• NACRES: NA.22

Properties

• concentration: 50 wt. % suspension in toluene
• bp: 400 °C (lit.)
• mp: 210 °C (lit.)
• SMILES string: N[Na]
• InChI: 1S/H2N.Na/h1H2;/q-1;+1
• InChI key: ODZPKZBBUMBTMG-UHFFFAOYSA-N

Description

General description

Sodium amide, an inorganic compound used in organic synthesis, is generally prepared by heating sodium metal in gaseous ammonia. It is used in some organic reactions like dehalogenation, deprotonation, anionic polymerization of ionic chains, and in cleavage of ketones.

Application

Reagent for:
Synthesis of allylic amines and amides
Synthesis of antibacterials
Aggregative activation and heterocyclic chemistry
Phenylation with diphenyliodonium chloride

Safety Information

• pictograms: GHS02,GHS08,GHS05,GHS07
• signalword: Danger
• hcodes: H225,H261,H304,H314,H336,H361d,H373,H412
• pcodes: P210 - P231 + P232 - P280 - P301 + P330 + P331 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Aquatic Chronic 3 - Asp. Tox. 1 - Eye Dam. 1 - Flam. Liq. 2 - Repr. 2 - Skin Corr. 1B - STOT RE 2 - STOT SE 3 - Water-react 2
• target_organs: Central nervous system
• supp_hazards: EUH014,EUH019,EUH029
• Storage Class: 4.3 - Hazardous materials which set free flammable gases upon contact with water
• wgk_germany: WGK 3
• flash_point_f: 39.2 °F - closed cup
• flash_point_c: 4 °C - closed cup
• ppe: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter