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Key Documents

248703

Sigma-Aldrich

4-(4-Nitrophenylsulfonyl)aniline

96%

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About This Item

Linear Formula:
O2NC6H4SO2C6H4NH2
CAS Number:
Molecular Weight:
278.28
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:

assay

96%

mp

169-171 °C (lit.)

SMILES string

Nc1ccc(cc1)S(=O)(=O)c2ccc(cc2)[N+]([O-])=O

InChI

1S/C12H10N2O4S/c13-9-1-5-11(6-2-9)19(17,18)12-7-3-10(4-8-12)14(15)16/h1-8H,13H2

InChI key

DMZVYFFBWHBWMO-UHFFFAOYSA-N


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J Uetrecht et al.
The Journal of pharmacology and experimental therapeutics, 245(1), 274-279 (1988-04-01)
Dapsone is an effective anti-inflammatory agent in conditions in which inflammation is mediated by neutrophils. Dapsone also has been associated with agranulocytosis. We found that neutrophils, which had been activated by a phorbol ester or opsonized zymosan, oxidized dapsone to
Stefano Pegoraro et al.
Nature communications, 8, 14193-14193 (2017-02-01)
Severe malaria is a life-threatening complication of an infection with the protozoan parasite Plasmodium falciparum, which requires immediate treatment. Safety and efficacy concerns with currently used drugs accentuate the need for new chemotherapeutic options against severe malaria. Here we describe

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