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146625

Sigma-Aldrich

Bathocuproinedisulfonic acid disodium salt hydrate

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About This Item

Empirical Formula (Hill Notation):
C26H18N2Na2O6S2 · xH2O
CAS Number:
1257642-74-2
Molecular Weight:
564.54 (anhydrous basis)
MDL number:
MFCD00149974
UNSPSC Code:
12352100
PubChem Substance ID:
24848788
NACRES:
NA.22

form

powder

mp

300 °C (lit.)

functional group

phenyl
sulfonic acid

SMILES string

O.[Na+].[Na+].Cc1nc2c(ccc3c(-c4ccccc4)c(c(C)nc23)S([O-])(=O)=O)c(-c5ccccc5)c1S([O-])(=O)=O

InChI

1S/C26H20N2O6S2.2Na.H2O/c1-15-25(35(29,30)31)21(17-9-5-3-6-10-17)19-13-14-20-22(18-11-7-4-8-12-18)26(36(32,33)34)16(2)28-24(20)23(19)27-15;;;/h3-14H,1-2H3,(H,29,30,31)(H,32,33,34);;;1H2/q;2*+1;/p-2

InChI key

ZAGWMJUGRCMNGX-UHFFFAOYSA-L

General description

Bathocuproine disulfonic acid (BCDS) is a stable Cu+ chelator and BCDS-Cu+ inhibits the HIV-1 wild type protease as well as a mutant HIV-1 protease lacking cysteine[1]. It is an extracellular copper chelator[2].

Application

Bathocuproinedisulfonic acid disodium salt hydrate was used as chelator in electron spin resonance spin trapping technique to study free radical generation in rats with acute sodium formate poisoning[3]. It was used as reagent for determination of Cu[4] and Cu-protein complexes[5].

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCG3838
BCCJ3707
BCCH8076
BCCH5213
BCCF6028

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D A Davis et al.
Archives of biochemistry and biophysics, 322(1), 127-134 (1995-09-10)
The protease encoded by the human immunodeficiency virus-1 (HIV-1) is essential for processing viral polyproteins which contain the enzymes and structural proteins required for the infectious virus. It was previously found that cupric chloride, in the presence of dithiothreitol or
Monirul Islam et al.
Frontiers in plant science, 11, 325-325 (2020-05-07)
The Earth's magnetic field, defined as the geomagnetic field (GMF), is an unavoidable environmental factor for all living organisms. Variation in the GMF intensity was found to affect the content of some nutrients and their associated channels and transporters in
M Matsushita et al.
Clinica chimica acta; international journal of clinical chemistry, 216(1-2), 103-111 (1993-07-16)
A method of protein determination has been developed which combines the biuret reaction and the copper(I)-bathocuproine chelate reaction. Protein in the specimen forms a Cu(2+)-protein chelate complex (biuret reaction) during the first step. Excess Cu2+ is reduced to Cu+ by
A E Dikalova et al.
Proceedings of the National Academy of Sciences of the United States of America, 98(24), 13549-13553 (2001-11-22)
Electron spin resonance spectroscopy has been used to study free radical generation in rats with acute sodium formate poisoning. The in vivo spin-trapping technique was used with alpha-(4-pyridyl-1-oxide)-N-t-butylnitrone (POBN), which reacts with free radical metabolites to form radical adducts, which
Suzie Kang et al.
International journal of molecular sciences, 21(20) (2020-10-22)
Copper is an essential metal ion that performs many physiological functions in living organisms. Deletion of Afmac1, which is a copper-responsive transcriptional activator in A. fumigatus, results in a growth defect on aspergillus minimal medium (AMM). Interestingly, we found that
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    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
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      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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