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F3401

2-Fluoroaniline

≥99%

Synonym(s):

1-Amino-2-fluorobenzene

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Pack SizeSKUAvailabilityPrice
25 g

Available to ship TODAYfromMILWAUKEE

$36.70

About This Item

Linear Formula:
FC6H4NH2
CAS Number:
Molecular Weight:
111.12
UNSPSC Code:
12352116
NACRES:
NA.25
PubChem Substance ID:
EC Number:
206-478-9
Beilstein/REAXYS Number:
1524219
MDL number:
Assay:
≥99%

$36.70


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Quality Segment

assay

≥99%

refractive index

n20/D 1.544 (lit.)

bp

182-183 °C (lit.)

mp

−29 °C (lit.)

density

1.151 g/mL at 25 °C (lit.)

SMILES string

Nc1ccccc1F

InChI

1S/C6H6FN/c7-5-3-1-2-4-6(5)8/h1-4H,8H2

InChI key

FTZQXOJYPFINKJ-UHFFFAOYSA-N

Biochem/physiol Actions

The metabolism and excretion of the xenobiotic compound 2-fluoroaniline is important due to human exposure in manufacturing. It is found to be very efficiently metabolized, primarily by 4-hydroxylation with subsequent sulfate or glucuronide formation. N-Acetylation is also observed. At least 80% of the dose is excreted in the urine within 24 hr. 2-Fluoroaniline exerts its nephrotoxic effect through 4-hyroxylation and subsequent p-benzoquinonimine formation.

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This Item
8.20565F3800F7601
assay

≥99%

assay

≥98.0% (GC)

assay

99%

assay

98%

Quality Level

100

Quality Level

200

Quality Level

-

Quality Level

100

refractive index

n20/D 1.544 (lit.)

refractive index

-

refractive index

n20/D 1.539 (lit.)

refractive index

n20/D 1.514 (lit.)

density

1.151 g/mL at 25 °C (lit.)

density

1.15 g/cm3 at 20 °C

density

1.173 g/mL at 25 °C (lit.)

density

1.216 g/mL at 25 °C (lit.)

mp

−29 °C (lit.)

mp

-29 °C

mp

-

mp

-

bp

182-183 °C (lit.)

bp

171-173 °C/1013 hPa

bp

187 °C/767 mmHg (lit.)

bp

86 °C/40 mmHg (lit.)


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Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1C - STOT RE 2

target_organs

Blood,hematopoietic system

Storage Class

3 - Flammable liquids

wgk

WGK 2

flash_point_f

140.0 °F - closed cup

flash_point_c

60 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter



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J Vervoort et al.
NMR in biomedicine, 4(6), 255-261 (1991-12-01)
The present study describes results from an in vivo 19F NMR study on rats exposed to the xenobiotic compound 2-fluoroaniline. Qualitative pharmacokinetics and the biotransformation of 2-fluoroaniline were studied after exposure to 50 mg/kg body wt 2-fluoroaniline. Accumulation and elimination
Suria Jahan et al.
Transfusion, 60(4), 769-778 (2020-03-19)
Platelet engraftment following cord blood (CB) transplantation remains a significant hurdle to this day. The uncontrolled growth of ice, a process referred to as ice recrystallization, is one of several mechanisms that lead to cell loss and decreased potency during
M A Valentovic et al.
Toxicology, 75(2), 121-131 (1992-11-01)
Aniline and its halogenated derivatives are widely used as chemical intermediates. The purpose of this study was to determine the hepatotoxic and nephrotoxic potential of the 2-haloanilines. Male Fischer 344 rats (n > or = 4) were injected (i.p.) with



Global Trade Item Number

SKUGTIN
F3401-25G-A04061833613917
F3401-500G-A04061837692215
F3401-100G-A04061833613863

Questions

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  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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