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MilliporeSigma

Complete LC-MS Analysis
for Consistent Results

We provide a premier selection of proven analytical tools and consumables that meet the requirements of scientists who primarily use the liquid chromatography-mass spectrometry (LC-MS) technique for separation and analysis of drugs and biomolecules, or for analytical assays. Our selection of columns, solvents, standards and sample preparation products are exclusively designed for LC-MS, meeting the critical need for purity. You can also find LC-MS applications and method development advice, in addition to comprehensive overviews of our product offerings for both small and large molecule LC-MS workflows, below.

Workflow

Sample Collection

Sample Collection

Sample Preparation

Sample Preparation

Standardization and Calibration

Standardization and Calibration

Chromatographic Separation & Analysis

Chromatographic Separation & Analysis

Chromatographic and Separation Analysis - Featured Articles

Sample Collection and Preparation - Featured Articles

Related Product Resources

Application Note: Lopinavir Assay Method
Application Note: Workflow for High-Throughput Glycoprofiling of Rituximab
Brochure: BIOshell™ U/HPLC Columns with Fused-Core® Technology
Brochure: A Practical Guide to HPLC
Brochure: HPLC and UHPLC Column Selection Guide
Flyer: Fentanyls
Poster: Tips & Tricks for Improved Quantitative and Qualitative LC-MS
Application Note: Workflow for Intact and Middle-Up Mass Analysis of Adalimumab
Brochure: Chiral HPLC Columns
Brochure: Supel™ BioSPME 96-Pin Devices
Application Note: Simplified LC-MS/MS Method for Glyphosate, AMPA and Glyfosinate in oat-based cereals

Application Note: LC-MS Analysis of PAHs in Grilled Meat
Application Note: Released N-linked Glycan Analysis Workflow of Adalimumab
Application Note: Peptide Mapping Analysis Workflow for Adalimumab
Application Note: LC-MS Analysis of 33 PFAS Compounds in 5 minutes – Ascentis® Express PFAS
Application Note: LC-MS Analysis of PFAS Compounds in EPA Methods 537.1, 533 and 8327 – Ascentis® Express PFAS
Flyer: Fast and High-Resolution LC-MS Separation with Ascentis® Express PFAS HPLC Columns
Flyer: Per- and polyfluoroalkyl substances (PFAS)
Application Guide: Drugs of Abuse

Related Product Categories
Liquid Handling & Dispensing
We offer an extensive portfolio of serological pipets and pipet controllers for molecular biology and cell culture, Pasteur and transfer pipets for general lab applications, volumetric pipets for titrations and analytical chemistry, and micropipette devices and pipette tips for your lab's liquid dispensing and liquid handling needs.
HPLC Columns
Achieve precise separations with our extensive HPLC column collection. Enhance retention, resolution, and selectivity. Order today.
Solvents
Your Solvent Source: Find the right fit with Supelco®, SigmaAldrich®, & SAFC® brands, covering analytical, lab, & biopharmaceutical uses. Order online.
Chromatography Standards
Certified Reference Materials & reference standards for chromatography-based testing applications including forensic and clinical toxicology analysis, diagnostic testing, therapeutic drug monitoring, cannabis testing, environmental analysis, pharmaceutical research, and food & beverage testing.
Milli-Q® Benchtop Lab Water Purification Systems
Find the water purification system that fits your lab’s needs. Compact Milli-Q® pure and ultrapure benchtop systems can meet your application, quality, volume, space and budget requirements.
Certified Reference Materials
Certified Reference Materials: CRMs for forensic, clinical, environmental, pharmaceutical, and food & beverage testing.
Chromatography & Spectroscopy Reagents
Explore our selection of high-quality analytical reagents for wet chemistry, chromatography, spectroscopy, analytical, titration, water quality control, and electrochemistry.
Related Applications
Solid Phase Extraction (SPE)
Solid phase extraction purifies samples for chromatographic analysis, improving data quality and protecting analytical columns.
QuEChERS Sample Prep Method
QuEChERS is a ‘Quick, Easy, Cheap, Effective, Rugged and Safe’ sample cleanup method used to prepare food and agricultural samples for pesticides analysis. QuEChERS is based on the Solid Phase Extraction (SPE) technique of sample preparation.
Sample Preparation by Filtration
Filtration separates substances to reduce sample complexity and increase analyte purity, improving analytical results.
Sample Purification
Purification methods for downstream analysis reduce sample complexity, remove interferences, and concentrate analytes for more accurate results.
Small Molecule HPLC
Small molecules are ions and compounds of molecular weight typically less than 900 daltons. These compounds can be effectively separated and analyzed by HPLC, UHPLC and LC-MS using mainly silica particles or monolithic stationary phases with a broad range of column chemistries (modifications).
Large Molecule HPLC
HPLC separates and identifies large biomolecules like proteins and peptides by pumping the sample through a sorbent-packed column.
Mass Spectrometry
Mass spectrometry (MS) is an analytical tool used to identify compounds, determine chemical structure, and assess isotopic abundance. In MS, samples are ionized, and the resulting ions are identified based on their mass-to-charge (m/z) ratios.
mRNA Therapeutics
Our comprehensive portfolio of products and services provides everything you need for mRNA synthesis, purification, and formulation for development and manufacturing.
RELATED SERVICES
Custom Reference Materials
Browse for high-quality Custom Reference Materials tailored to your specific analytical applications from Supelco. Get your quote now!
Custom HPLC Columns
Supelco offers custom packed HPLC columns for challenging applications; order non-stock product columns with various particle and chemistry options.
Inventory Management
Cerilliant® team provides custom packaging, inventory storage, management, and worldwide distribution of client reference materials.
Analytical Testing for Reference Standards
Enjoy the benefits of our high-quality customized analytical testing and organic synthesis services spanning a wide variety of compounds and techniques for support of client-specific reference materials.
Custom SPE Tubes & 96-Well Plates
Solid-phase extraction (SPE) offers rapid sample preparation and purification for chromatographic analysis, customizable to analytical needs.
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