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Key Documents

SAB4502683

Sigma-Aldrich

Anti-p70 S6 Kinase antibody produced in rabbit

affinity isolated antibody

Synonym(s):

70 kDa ribosomal protein S6 kinase 1, Ribosomal protein S6 kinase I, S6K, S6K1, p70 S6 kinase α

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About This Item

MDL number:
MFCD01092452
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 59 kDa

species reactivity

rat, human, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:40000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

P23443

UniProt accession no.

P23443

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... RPS6KB1(6198)

General description

Ribosomal protein S6 kinase, 70kDa, polypeptide 1 (RPS6KB1) belongs to the AGC kinase subfamily and comprises a catalytic domain, a linker region, and a putative autoinhibitory domain, in addition to the N-terminal and C-terminal domain. The RPS6KB1 gene is located on human chromosome 17q23.1. It exists in multiple isoforms due to alternative splice events.

Immunogen

The antiserum was produced against synthesized peptide derived from human p70 S6 Kinase.

Immunogen Range: 195-244

Application

Anti-p70 S6 Kinase antibody produced in rabbit has been used in western blotting (1:1000).

Biochem/physiol Actions

Ribosomal protein S6 kinase, 70kDa, polypeptide 1 (RPS6KB1) undergoes acetylation, phosphorylation, and ubiquitination. It is involved in a variety of functions including glucose homeostasis, cell survival, and proliferation. RPS6KB1 also participates in cell structure and organization. It is implicated in ovarian cancer progression, muscle hypertrophy, aging, immunity, and memory. RPS6KB1 also regulates the replication and transcription of mumps virus (MuV).

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Yu-Di Zhu et al.
Molecular medicine reports, 18(3), 3403-3410 (2018-08-02)
Despite advances in management, bladder cancer remains a principal cause of cancer‑associated complications. Tumor necrosis factor receptor superfamily member 14 (TNFRSF14) is dysregulated in certain types of cancer; however, limited data are available on the expression and function of TNFRSF14 in
Carman K M Ip et al.
Expert opinion on therapeutic targets, 16(6), 619-630 (2012-05-09)
The p70 S6 kinase (p70(S6K)) is frequently active in ovarian and a wide range of cancer types, and it has a crucial role in several processes considered hallmarks of cancer. Therefore, blocking p70(S6K) expression or activity may present a promising
Abdullah R Ahmed et al.
Scientific reports, 9(1), 3408-3408 (2019-03-06)
Knowledge of protein signalling pathways in the working cell is seen as a primary route to identifying and developing targeted medicines. In recent years there has been a growing awareness of the importance of the mTOR pathway, making it an
Kelsey Briggs et al.
Journal of virology, 94(12) (2020-04-17)
Mumps virus (MuV) caused the most viral meningitis before mass immunization. Unfortunately, MuV has reemerged in the United States in the past several years. MuV is a member of the genus Rubulavirus, in the family Paramyxoviridae, and has a nonsegmented

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