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W4394

Sigma-Aldrich

Withaferin A

≥95% (HPLC)

同義詞:

5,6-环氧-4,27-二羟基-1-氧代-2,24-二烯醇内酯, Withaferine A

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About This Item

經驗公式（希爾表示法）:
C28H38O6
CAS號碼:
5119-48-2
分子量：:
470.60
MDL號碼:
MFCD10687098
分類程式碼代碼:
12352211
PubChem物質ID:
329830709
NACRES:
NA.77
暫時無法取得訂價和供貨情況

生物源

plant (Withania somnifera)

品質等級

200

化驗

≥95% (HPLC)

形狀

powder

mp

252-253 °C

官能基

epoxy
ketone

運輸包裝

ambient

儲存溫度

2-8°C

SMILES 字串

C[C@H]([C@H]1CC(C)=C(CO)C(=O)O1)[C@H]2CC[C@H]3[C@@H]4C[C@H]5O[C@]56[C@@H](O)C=CC(=O)[C@]6(C)[C@H]4CC[C@]23C

InChI

1S/C28H38O6/c1-14-11-21(33-25(32)17(14)13-29)15(2)18-5-6-19-16-12-24-28(34-24)23(31)8-7-22(30)27(28,4)20(16)9-10-26(18,19)3/h7-8,15-16,18-21,23-24,29,31H,5-6,9-13H2,1-4H3/t15-,16-,18+,19-,20-,21+,23-,24+,26+,27-,28+/m0/s1

InChI 密鑰

DBRXOUCRJQVYJQ-CKNDUULBSA-N

相關類別

應用

用醉茄素 A 处理 HEK293 细胞，研究其对囊性纤维化炎症的影响。[1]

生化／生理作用

对肿瘤细胞具有细胞毒性的甾体内酯。保护作用归因于抗脂质过氧化、抗氧化和解毒功能。
醉茄素 A 是从植物中分离得到的甾体内酯 。具有强大的抗炎属性，可抑制 NF-κ 的活化B 信号通路。[2]醉茄素 A 的抗肿瘤活性是由于它能够通过结合膜联蛋白 II 和破坏 F 肌动蛋白交联来改变细胞骨架结构。[3]醉茄素 A 通过与波形蛋白和肌动蛋白结合抑制血管生成。[4]

準備報告

醉茄素 A 在 1 mg/mL 甲醇中生成澄清、无色溶液。

儲存類別代碼

13 - Non Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

438.8 °F

閃點（°C）

226 °C

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分析證明 (COA)

Lot/Batch Number
SLCN2765
SLCN0222
SLCM7668
SLCM9129
SLCM8033

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Inhibition of NFκB by the natural product Withaferin A in cellular models of Cystic Fibrosis inflammation
Maitra R et al
Journal of Inflammation (London, England), 6, doi: 10-doi: 10 (2009)
Silvia D Stan et al.
Nutrition and cancer, 60 Suppl 1, 51-60 (2008-11-15)
Withaferin A (WA) is derived from the medicinal plant Withania somnifera that has been safely used for centuries in the Indian Ayurvedic medicine for treatment of various ailments. We now demonstrate that WA treatment causes G2 and mitotic arrest in
Paola Bargagna-Mohan et al.
Chemistry & biology, 14(6), 623-634 (2007-06-23)
The natural product withaferin A (WFA) exhibits antitumor and antiangiogenesis activity in vivo, which results from this drug's potent growth inhibitory activities. Here, we show that WFA binds to the intermediate filament (IF) protein, vimentin, by covalently modifying its cysteine
Huanjie Yang et al.
PloS one, 7(8), e41214-e41214 (2012-08-23)
The medicinal plant Withania somnifera has been used for over centuries in Indian Ayurvedic Medicine to treat a wide spectrum of disorders. Withaferin A (WA), a bioactive compound that is isolated from this plant, has anti-inflammatory, immuno-modulatory, anti-angiogenic, and anti-cancer
Abhinav Grover et al.
BMC genomics, 13 Suppl 7, S20-S20 (2013-01-11)
Leishmaniasis is caused by several species of leishmania protozoan and is one of the major vector-born diseases after malaria and sleeping sickness. Toxicity of available drugs and drug resistance development by protozoa in recent years has made Leishmaniasis cure difficult
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Questions

1–4 of 4 Questions  

  1. How does the storage temperature relate to shipping conditions?

    1 answer

    1. The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.

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  2. What is the solution stability of Product W4394, Withaferin A?

    1 answer

    1. Sigma-Aldrich does not test the Product W4394, Withaferin A, for solution stability. Information in our files indicates that although it is best to use freshly prepared solution when possible. However, if stock solutions must be stored, we would recommend they be stored in frozen aliquots at -20°C or below for about one month.

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  3. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  4. How does one solubilize Product W4394, Withaferin A?

    1 answer

    1. Sigma-Aldrich tests Product W4394, Withaferin A, for solubility using methanol at a concentration of 1 mg/mL. Information in our files indicates that it is also soluble in DMSO and ethanol.

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