U8881

UCL 1684 ditrifluoroacetate hydrate

• 同義詞: 6,12,19,20,25,26-hexahydro- 5,27:13,18:21,24-Trietheno-11,7-metheno-7H-dibenzo[b,m][1,5,12,16]tetraazacyclotricosine-5,13-diium ditrifluoroacetate hydrate
• 線性公式: (C₃₄H₃₀N₄)²⁺ · (C₂F₃O₂^-)₂ · xH₂O
• CAS號碼: 201147-19-5
• 分子量：: 720.66 (anhydrous basis)
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24900684
• NACRES: NA.77

屬性

• 顏色: white to off-white
• 溶解度: DMSO: 10 mg/mL
• SMILES 字串: [H]O[H].FC(F)(C(O)=O)F.FC(F)(C(O)=O)F.C12=CC=CC=C1C(NCC3=CC=C(CNC4=CC=[N+](C5)C6=C4C=CC=C6)C=C3)=CC=[N+]2CC7=CC=CC5=C7
• InChI: 1S/C34H28N4.2C3H3F3O2.H2O/c1-3-10-33-29(8-1)31-16-18-37(33)23-27-6-5-7-28(20-27)24-38-19-17-32(30-9-2-4-11-34(30)38)36-22-26-14-12-25(13-15-26)21-35-31;2*4-3(5,6)1-2(7)8;/h1-20H,21-24H2;2*1H2,(H,7,8);1H2/b35-31+,36-32+;;;
• InChI 密鑰: YROHEYZVNZITJN-DDVHGCDCSA-N

描述

應用

UCL 1684 ditrifluoroacetate hydrate has been used for analyzing the mechanism for ammonium-mediated displacement of the protonated analyte from analyte-trifluoroacetic acid (TFA) ion-pair. UCL 1684 has also been used as a potassium channel inhibitor to study CNP (C-type natriuretic peptide)-induced relaxations in pig coronary arteries.

生化／生理作用

UCL 1684 is a potent non-peptide blocker of the apamin-sensitive Ca²⁺-activated K⁺ channel. It comprises two quinolinium rings and is similar to apamin arginine residue. UCL 1684 inhibits calcium-activated K current (Kslow) and modulates islet β-cell.

特點和優勢

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

準備報告

UCL 1684 ditrifluoroacetate hydrate is soluble in water at 10 mg/ml.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)