推薦產品
化驗
≥98% (HPLC)
形狀
solid
顏色
white
溶解度
DMSO: >5 mg/mL at 60 °C
H2O: insoluble
起源
Boehringer Ingelheim
SMILES 字串
CCCc1nc2c(C)cc(cc2n1Cc3ccc(cc3)-c4ccccc4C(O)=O)-c5nc6ccccc6n5C
InChI
1S/C33H30N4O2/c1-4-9-30-35-31-21(2)18-24(32-34-27-12-7-8-13-28(27)36(32)3)19-29(31)37(30)20-22-14-16-23(17-15-22)25-10-5-6-11-26(25)33(38)39/h5-8,10-19H,4,9,20H2,1-3H3,(H,38,39)
InChI 密鑰
RMMXLENWKUUMAY-UHFFFAOYSA-N
基因資訊
human ... AGTR1(185)
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應用
替米沙坦已作为 AT1 受体拮抗剂用于研究其对心肌梗死小鼠模型的影响。本研究报道替米沙坦可抑制 CCN1 上调，降低 CCN2 水平心房心肌细胞 。替米沙坦也被用于评价其对心肌梗死小鼠肾皮质 CCN1 表达的影响 。此外，已在结直肠癌小鼠模型中测试替米沙坦检测其抑制肿瘤生长的疗效 。
生化／生理作用
替米沙坦是一种非肽类 1 血管紧张素受体拮抗剂。
特點和優勢
该化合物由 Boehringer Ingelheim 开发。要浏览其他制药公司开发的化合物列表批准的药物/候选药物的列表， 点击这里 。
这种化合物是 ADME 毒性研究的特色产品。点击此处发现更多特色 ADME 毒性产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
準備報告
替米沙坦可溶于 DMSO，浓度大于 5 mg/mL。不溶于水。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
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