推薦產品
生物源
rabbit
共軛
unconjugated
抗體表格
whole antiserum
抗體產品種類
primary antibodies
無性繁殖
polyclonal
包含
15 mM sodium azide
物種活性
chicken, rat, mouse
技術
western blot: 1:100 using rat or mouse brain tissue extract
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... MAPT(4137)
一般說明
Tau(τ),也称为MAPT(微管相关蛋白tau),由位于人染色体17q21.3上的基因编码。它在神经元中高表达,但在轴突中最显著。
Tau(τ),也称为微管相关蛋白tau(MAPT),由位于人染色体17q21.3上的基因编码。它在神经元中高表达,但在轴突中最显著。Tau是热稳定微管相关蛋白(MAP),对应的分子量为55- 65 kDa。
特異性
此抗体显示了广泛的物种反应性。抗-τ不会与MAP1、MAP2或微管蛋白发生反应。抗体与τ发生反应,即两种主要类别的热稳定的微管相关蛋白(MAP)之一。
免疫原
τ 来自鸡胚脑微管的蛋白质。
應用
兔抗τ (Tau)抗体已用作免疫印迹分析中的一抗。
生化/生理作用
去除Tau (τ)可导致发育迟缓和学习障碍。它参与了阿尔茨海默病(AD)的发病机制。Tau蛋白有助于微管结构的组装和维护。
编码tau蛋白的MAPT基因变异可导致额颞痴呆。Tau蛋白是许多激酶的底物。
免責聲明
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的人类或动物食用或应用。
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儲存類別代碼
10 - Combustible liquids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
從最近期的版本中選擇一個:
分析證明 (COA)
Lot/Batch Number
Tau pathology in Alzheimer disease and other tauopathies
Iqbal K, et al.
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1739(2-3), 198-210 (2005)
Lieven Declercq et al.
Molecular imaging, 15 (2016-04-01)
Early clinical results of two tau tracers, [(18)F]T808 and [(18)F]T807, have recently been reported. In the present study, the biodistribution, radiometabolite quantification, and competition-binding studies were performed in order to acquire comparative preclinical data as well as to establish the
Michael Briese et al.
Nucleic acids research, 44(4), e33-e33 (2015-10-16)
Most RNAs within polarized cells such as neurons are sorted subcellularly in a coordinated manner. Despite advances in the development of methods for profiling polyadenylated RNAs from small amounts of input RNA, techniques for profiling coding and non-coding RNAs simultaneously
J H Su et al.
Acta neuropathologica, 96(5), 463-471 (1998-11-26)
Plaque-associated dystrophic neurites are a common pathological feature in the brains of patients with Alzheimer's disease (AD). In the present study, we investigated the relative abundance and progressive transformation of the amyloid precursor protein (APP), neurofilament (NF) and paired helical
Distinct neuroanatomical correlates of neuropsychiatric symptoms in the three main forms of genetic frontotemporal dementia in the GENFI cohort
Sellami L, et al.
Journal of Alzheimer'S Disease, 1-16 (2018)
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