T5443

Tyrphostin AG 825

≥92.5%

• 同義詞: 5-[(Benzothiazol-2-yl)thiomethyl]-4-hydroxy-3-methoxybenzylidenecyanoacetamide, Tyrphostin C15
• 經驗公式（希爾表示法）: C₁₉H₁₅N₃O₃S₂
• CAS號碼: 149092-50-2
• 分子量：: 397.47
• MDL號碼: MFCD01074971
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329826823
• NACRES: NA.77

屬性

• 品質等級: 200
• 化驗: ≥92.5%
• 形狀: powder
• 溶解度: DMSO: soluble; methanol: soluble
• 儲存溫度: −20°C
• SMILES 字串: COc1cc(cc(CSc2nc3ccccc3s2)c1O)\C=C(/C#N)C(N)=O
• InChI: 1S/C19H15N3O3S2/c1-25-15-8-11(6-12(9-20)18(21)24)7-13(17(15)23)10-26-19-22-14-4-2-3-5-16(14)27-19/h2-8,23H,10H2,1H3,(H2,21,24)/b12-6+
• InChI 密鑰: KXDONFLNGBQLTN-WUXMJOGZSA-N

描述

應用

Tyrphostin AG 825 has been used to study its effects on iodide uptake in EMT6 cells¹.

生化／生理作用

Tyrphostin AG 825 has been used in combination with hypericin-mediated photodynamic therapy (HY-PDT) for evaluating its therapeutic effects in HER2 overexpressing human breast cancer cells. This study reported that AG 825 combination increased the induction of cell death, HER2 degradation and inhibited colony formation in cancer cells².

EGF receptor tyrosine kinase inhibitor, inactive against IGF-1 Receptor.

特點和優勢

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

準備報告

Tyrphostin AG 825 is soluble in DMSO and methanol.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)