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Merck
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文件

T4949

Sigma-Aldrich

Taprostene sodium salt

≥98% (HPLC)

同義詞:

Rheocyclan, Sodium 3-[(Z)-[(3aR,4R,5R,6aS)-4-[(1E,3S)-3-cyclohexyl-3-hydroxy-1-propenyl]hexahydro-5-hydroxy-2H-cyclopenta[b]furan-2-ylidene]methyl]benzoate

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About This Item

經驗公式（希爾表示法）:
C24H29NaO5
CAS號碼:
87440-45-7
分子量：:
420.47
MDL號碼:
MFCD05664743
分類程式碼代碼:
12352202
PubChem物質ID:
24724631
NACRES:
NA.77

化驗

≥98% (HPLC)

顏色

off-white

mp

173-182.5 °C (lit.)

溶解度

H2O: 26 mg/mL

儲存溫度

2-8°C

SMILES 字串

[Na+].[H][C@]12C[C@@H](O)[C@H](\C=C\[C@@H](O)C3CCCCC3)[C@@]1([H])C\C(O2)=C\c4cccc(c4)C([O-])=O

InChI

1S/C24H30O5.Na/c25-21(16-6-2-1-3-7-16)10-9-19-20-13-18(29-23(20)14-22(19)26)12-15-5-4-8-17(11-15)24(27)28;/h4-5,8-12,16,19-23,25-26H,1-3,6-7,13-14H2,(H,27,28);/q;+1/p-1/b10-9+,18-12-;/t19-,20-,21-,22-,23+;/m1./s1

InChI 密鑰

KPQVOJYDUCZQEQ-REHYUDDHSA-M

應用

Taprostene has been used as an IP receptor agonist and was found to increase cAMP expression in human bronchial epithelial cells1.

生化／生理作用

Highly selective IP1 prostanoid receptor agonist.

準備報告

Taprostene is soluble in water at 26 mg/ml.

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H302 + H312 + H332

危險分類

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

分析證明 (COA)

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M Spiecker et al.
Haemostasis, 27(4), 184-192 (1997-07-01)
We investigated the in vitro thrombolytic effects of streptokinase, urokinase, alteplase and saruplase, alone or in combination, with the prostacyclin analogues, iloprost and taprostene. Human platelet-rich plasma was stimulated with collagen (1 microgram/ml) to generate thrombi containing platelets and fibrin.
O Michel et al.
ORL; journal for oto-rhino-laryngology and its related specialties, 56(6), 305-309 (1994-11-01)
A probable relation between prostaglandin formation and the pathophysiology of hearing loss led to the application of the potent vasodilator prostacyclin in the treatment of inner ear disorders. Two drugs may be administered to humans: (1) unstable natural prostacyclin (epoprostenol)
A M Lefer et al.
Methods and findings in experimental and clinical pharmacology, 16(9), 623-631 (1994-11-01)
We examined the effects of taprostene (2.5 x 10(-8) M to 1 x 10(-7) M), a stable prostacyclin analog, on PMN-endothelial interaction (i.e., adherence) and subsequent vasocontraction and endothelial dysfunction. Taprostene effectively inhibited the adherence of leukotriene B4-stimulated autologous cat
M Heinz et al.
VASA. Zeitschrift fur Gefasskrankheiten, 25(1), 65-72 (1996-01-01)
In a double blind pilot study, we examined the effects of the stable prostacyclin derivate taprostene compared to a combination of aspirin and dipyridamole on platelet uptake and clinical outcome after peripheral percutaneous angioplasty. Taprostene was administered to 19 patients
R L Jones et al.
Prostaglandins, leukotrienes, and essential fatty acids, 72(4), 289-299 (2005-03-15)
The possibility that the prostacyclin analogues AFP-07 and cicaprost relax saphenous vein preparations of pig, guinea-pig and rabbit by simultaneously activating prostanoid EP4 and IP (prostacyclin) receptors was investigated using the high-affinity EP4 antagonist GW 627368. The IP receptor system
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