T1783

Tobramycin sulfate salt 硫酸盐

aminoglycoside antibiotic

• 同義詞: Nebramycin Factor 6 sulfate
• 經驗公式（希爾表示法）: C₁₈H₃₇N₅O₉ · xH₂SO₄
• 分子量：: 467.51 (free base basis)
• MDL號碼: MFCD00133864
• 分類程式碼代碼: 51281677
• PubChem物質ID: 329826686
• NACRES: NA.85

屬性

• 生物源: Streptomyces tenebrarius
• 品質等級: 200
• 形狀: powder
• 效力: 634-739 μg per mg
• 儲存條件: (Keep container tightly closed in a dry and well-ventilated place. Hygroscopic.)
• 顏色: white to off-white
• 溶解度: H₂O: soluble 50 mg/mL
• 抗生素活性譜: Gram-negative bacteria
• 作用方式: protein synthesis | interferes
• 儲存溫度: 2-8°C
• SMILES 字串: OS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](N)C[C@@H]1O
• InChI: 1S/C18H37N5O9.H2O4S/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18;1-5(2,3)4/h5-18,24-28H,1-4,19-23H2;(H2,1,2,3,4)/t5-,6+,7+,8-,9+,10+,11-,12+,13+,14-,15+,16-,17+,18+;/m0./s1
• InChI 密鑰: ZEUUPKVZFKBXPW-TWDWGCDDSA-N

描述

一般說明

Chemical structure: aminoglycoside

應用

Tobramycin is an aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the pseudomonas species. It is not effective against Enterococci. It is used to inhibit bacterial protein synthesis at the level of 30S (16S rRNA) and 70S ribosomal complex assembly. It is used to treat pseudomonas aeruginosa lung infections and is used in combination with other antibiotics to treat urinary tract infections, gynecologic infections, peritonitis, endocarditis, pneumonia, sepsis, respiratory infections, osteomyelitis and other soft-tissue infections. It is a potential therapy for sinus infections[1]. Product T1783 has been used to study antibiotic resistance[2].

生化／生理作用

Tobramycin binds irreversibly to one of two aminoglycoside binding sites on the 30 S ribosomal subunit, inhibiting bacterial protein synthesis. Tobramycin may also destabilize bacterial membranes by binding to 16 S r-RNA. It inhibits translocation and elicits miscoding. Tobramycin binds to an RNA aptamer, which is structurally similar to the A site of 16S rRNA[2].

Tobramycin sulfate is an aminoglycoside.
Mode of Action: Binds to 70S ribosomal subunit; inhibits translocation; elicits miscoding.
Spectrum of Activity: Gram negative bacteria. Not effective against Enterococci.

包裝

100MG,500MG

注意

吸湿

其他說明

Keep container tightly closed in a dry and well-ventilated place. Hygroscopic.

安全資訊

• 象形圖: GHS08,GHS07
• 訊號詞: Danger
• 危險聲明: H312 + H332,H360
• 防範說明: P202 - P261 - P280 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313
• 危險分類: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Repr. 1B
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges