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Merck
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重要文件

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T0675

Sigma-Aldrich

[D-Ala2]-Deltorphin II

≥97% (HPLC)

同義詞:

Tyr-D-Ala-Phe-Glu-Val-Val-Gly amide

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About This Item

經驗公式（希爾表示法）:
C38H54N8O10
CAS號碼:
122752-16-3
分子量：:
782.88
MDL號碼:
MFCD00080072
分類程式碼代碼:
12352209
PubChem物質ID:
24899907
NACRES:
NA.32
暫時無法取得訂價和供貨情況

生物源

synthetic (organic)

品質等級

200

化驗

≥97% (HPLC)

形狀

powder

儲存溫度

−20°C

SMILES 字串

CC(C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)C)C(=O)NCC(N)=O

InChI

1S/C38H54N8O10/c1-20(2)31(37(55)41-19-29(40)48)46-38(56)32(21(3)4)45-35(53)27(15-16-30(49)50)43-36(54)28(18-23-9-7-6-8-10-23)44-33(51)22(5)42-34(52)26(39)17-24-11-13-25(47)14-12-24/h6-14,20-22,26-28,31-32,47H,15-19,39H2,1-5H3,(H2,40,48)(H,41,55)(H,42,52)(H,43,54)(H,44,51)(H,45,53)(H,46,56)(H,49,50)/t22-,26+,27+,28+,31+,32+/m1/s1

InChI 密鑰

NUNBRHVOPFWRRG-RCEFDBTISA-N

基因資訊

human ... OPRD1(4985) , OPRK1(4986) , OPRM1(4988)
mouse ... Oprd1(18386) , Oprm1(18390)
rat ... Oprd1(24613) , Oprm1(25601)

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Amino Acid Sequence

Tyr-Ala-Phe-Glu-Val-Val-Gly-NH2

生化／生理作用

Selective δ2 opioid receptor agonist

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

從最近期的版本中選擇一個：

分析證明 (COA)

Lot/Batch Number
SLCC1825
SLBZ8418
SLBS8359
SLBR8129V
SLBP5876V

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A Capasso
Medicinal chemistry (Shariqah (United Arab Emirates)), 5(1), 1-6 (2009-01-20)
Recently, we have demonstrated that substitution of 1,2,3,4 tetrahyidroisoquinoline-3- carboxylic acid (Tic) in place of Gly2 in dynorphin A-(1-13)-NH2 (DYN) analogue (A) decreased the affinity to the kappa, delta, and micro receptors, and kappa selectivity. The doubly substituted analogue [2',6'-dimethyl-L-tyrosine
Aaron C Overland et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(42), 13264-13273 (2009-10-23)
Coactivation of spinal alpha(2)-adrenergic receptors (ARs) and opioid receptors produces antinociceptive synergy. Antinociceptive synergy between intrathecally administered alpha(2)AR and opioid agonists is well documented, but the mechanism underlying this synergy remains unclear. The delta-opioid receptor (DOP) and the alpha(2A)ARs are
Michael A Ansonoff et al.
Psychopharmacology, 210(2), 161-168 (2010-03-25)
During the past decade, substantial evidence has documented that opioid receptor heterodimers form in cell lines expressing one or more opioid receptors. More recent studies have begun to investigate whether heterodimer formation also occurs in vivo. We have used opioid
Leonid N Maslov et al.
Life sciences, 84(19-20), 657-663 (2009-02-28)
This study aims to investigate the role of peripheral delta(2) opioid receptors in cardiac tolerance to ischemia/reperfusion injury and to examine the contribution of PKC, TK, K(ATP) channels and the autonomic nervous system in delta(2) cardioprotection. Deltorphin II and various
Michael M Morgan et al.
Neural plasticity, 2009, 516328-516328 (2009-03-07)
Chronic morphine administration shifts delta-opioid receptors (DORs) from the cytoplasm to the plasma membrane. Given that microinjection of morphine into the PAG produces antinociception, it is hypothesized that the movement of DORs to the membrane will allow antinociception to the
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