SRP8055

Tim-3 (human): FC (human)

recombinant, expressed in CHO cells, ≥98% (SDS-PAGE)

• 同義詞: HAVcr-2, T-cell immunoglobulin and mucin domain-containing protein 3, TIM3, TIMD3
• 分類程式碼代碼: 12352200
• NACRES: NA.32

屬性

• 生物源: human
• 重組細胞: expressed in CHO cells
• 化驗: ≥98% (SDS-PAGE)
• 形狀: lyophilized
• 分子量: monomer 48 kDa by calculation
• 包裝: pkg of 100 μg
• 儲存條件: avoid repeated freeze/thaw cycles
• 雜質: <0.06 EU/μg endotoxin, tested
• 顏色: white
• UniProt登錄號: Q8TDQ0
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 基因資訊: human ... HAVCR2(84868)

描述

一般說明

The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. Tim-3, a type I transmembrane protein, contains an immunoglobulin and a mucin-like domain in its extracellular portion and a tyrosine phosphorylation motif in its cytoplasmic portion. TIM-3 is preferentially expressed on Th1 and Tc1 cells, and generates an inhibitory signal resulting in apoptosis of Th1 and Tc1 cells. TIM-3 is also expressed on some dendritic cells and can mediate phagocytosis of apoptotic cells and cross-presentation of antigen. Tim-3 functions to inhibit aggressive Th1-mediated auto- and alloimmune responses. Tim-3 pathway blockade by administration of Tim-3:Fc fusion protein accelerates diabetes in nonobese diabetic mice, causes hyperproliferation of Th1 cells and Th1 cytokine release in an experimental autoimmune encephalomyelitis (EAE) model and prevents acquisition of transplantation tolerance induced by costimulation blockade.

外觀

Lyophilized from 0.2 μm-filtered solution in PBS.

重構

Reconstitute at 100 μg/mL in sterile PBS.

其他說明

The extracellular domain of human Tim-3 (aa 22-200) is fused to the N-terminus of the Fc region of human IgG1.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable