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Merck
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重要文件

SRP6284

Sigma-Aldrich

鸢尾素 人

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

同義詞:

FNDC5 (切割), 含Ⅲ型纤连蛋白域蛋白2(切割), 含Ⅲ型纤连蛋白域蛋白5

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About This Item

分類程式碼代碼:
12352202
暫時無法取得訂價和供貨情況

生物源

human

重組細胞

expressed in E. coli

化驗

≥95% (SDS-PAGE)

形狀

lyophilized powder

分子量

~13 kDa

包裝

pkg of 10 μg

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

基因資訊

human ... FNDC5(252995)

一般說明

鸢尾素是最近鉴定的由小鼠和人类骨骼肌分泌的运动诱导激素。鸢尾素是从I型膜蛋白FNDC5(纤连蛋白 III 型域包含蛋白 5)上切割出来的。[1][2] FNDC5主要表达于肌肉中。肾、肝和肺中也含有低水平的mRNA。[2] FNDC5基因位于人染色体1p35.1上。[3]

生化/生理作用

鸢尾素(Irisin)能够激活米色脂肪细胞(米色细胞的基因表达模式与白色或棕色脂肪不同,并且对多肽激素鸢尾素更敏感),并通过增加能量消耗来改善全身代谢。[1][2]它主要负责将白色脂肪转化为棕色脂肪。这种转化增强了代谢解偶联和热量消耗。 [1]鸢尾素始终与运动对细胞代谢的有益反应有关。[2]在肥胖和2型糖尿病患者中,低水平的循环鸢尾素是脂肪组织和肌肉的特征。[4]

外觀

从PBS中冻干。

重構

使用100μL 无菌水重悬至 0.1 mg/mL。

儲存類別代碼

13 - Non Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Endre Kristóf et al.
Experimental cell research, 377(1-2), 47-55 (2019-02-23)
Brown and beige adipocytes contribute significantly to the regulation of whole body energy expenditure and systemic metabolic homeostasis not exclusively by thermogenesis through mitochondrial uncoupling. Several studies have provided evidence in rodents that brown and beige adipocytes produce a set
Rujun Zeng et al.
Bioscience trends, 12(6), 580-586 (2019-01-25)
Irisin is a myokine secreted from the cleavage of fibronectin type III domain-containing protein 5 (FNDC5) and has an effect on bone formation. There are limited studies about the structure of irisin and its functional unit. In order to clarify
Is irisin a human exercise gene?
Timmons JA
Nature, 488, E9-10 (2012)
Elke Albrecht et al.
Molecular metabolism, 34, 124-135 (2020-03-18)
Considerable uncertainty remains regarding the veracity of measuring myokine irisin more than seven years after its original description. Unresolved issues include the nature of transcription of the irisin precursor fibronectin type III domain containing 5 (FNDC5) gene across species, the
Gianluca Vadalà et al.
Cells, 9(6) (2020-06-21)
Physical exercise favors weight loss and ameliorates articular pain and function in patients suffering from osteoarthritis. Irisin, a myokine released upon muscle contraction, has demonstrated to yield anabolic effects on different cell types. This study aimed to investigate the effect

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