SRP6214

EGF Receptor human

recombinant, expressed in CHO cells, ≥95% (SDS-PAGE)

• 同義詞: ErbB1
• 分類程式碼代碼: 12352200

屬性

• 生物源: human
• 重組細胞: expressed in CHO cells
• 化驗: ≥95% (SDS-PAGE)
• 形狀: lyophilized powder
• 分子量: 97.5 kDa
• 雜質: <1 EU/μg endotoxin (LAL test)
• UniProt登錄號: P01133
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 基因資訊: human ... EGFR(1950)

描述

一般說明

EGF Receptor (EGFR, ErbB1) is a transmembrane protein that exerts tyrosine kinase activity upon ligand induced activation. EGFR can be activated by binding EGF or at least six other structurally related protein ligands, including TGFα, HBEGF, βcellulin (BTC), Amphiregulin, Epiregulin, and Epigen. Upon activation, EGFR initiates a signaling cascade which includes dimerization and internalization, tyrosine phosphorylation, DNA synthesis of target genes, and, ultimately, cell proliferation. EGFR signaling plays a role in the growth and differentiation of normal cells, but elevated EGFR activity is correlated with the development and pathogenesis of certain cancers. Recombinant soluble human EGFR is a 621 amino acid glycoprotein comprising the extracellular domain of EGFR, and migrates at an apparent MW of 97.5 kDa by SDS-PAGE analysis under reducing conditions.

外觀

Sterile filtered through a 0.2 micron filter. Lyophilized from 10 mM Sodium Phosphate, pH 7.5.

重構

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable