暫時無法取得訂價和供貨情況
重組細胞
expressed in baculovirus infected Sf9 cells
產品線
PRECISIO® Kinase
化驗
≥70% (SDS-PAGE)
形狀
buffered aqueous glycerol solution
比活性
24-32 nmol/min·mg
分子量
~72 kDa
NCBI登錄號
運輸包裝
dry ice
儲存溫度
−70°C
基因資訊
human ... EPHA1(2041)
一般說明
EPHA1 is a member of the Eph family of receptor tyrosine kinases that have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the Eph subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. EPHA1 seems to be a marker of the differentiated normal epidermis and its downregulation in nonmelanoma skin cancer may contribute to carcinogenesis of these very frequent human tumors. EPHA1 represents a new potential prognostic marker and therapeutic target in nonmelanoma skin cancer.
外觀
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
準備報告
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
法律資訊
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Mechanisms and functions of Eph and ephrin signalling.
Klas Kullander et al.
Nature reviews. Molecular cell biology, 3(7), 475-486 (2002-07-03)
Christian Hafner et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 19(10), 1369-1377 (2006-07-25)
Eph receptors and ephrin ligands represent the largest family of receptor tyrosine kinases. Beyond their well-defined meaning in developmental processes, these molecules also have important functions in adult human tissues and cancer. However, the Eph/ephrin expression profile in human skin
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