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Merck
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重要文件

SRP5024

Sigma-Aldrich

EIF2AK3 (563-1115), active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

同義詞:

DKFZp781H1925, HRI, PEK, PERK, WRS

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About This Item

分類程式碼代碼:
12352200
NACRES:
NA.77
暫時無法取得訂價和供貨情況

重組細胞

expressed in E. coli

產品線

PRECISIO® Kinase

化驗

≥70% (SDS-PAGE)

形狀

buffered aqueous glycerol solution

比活性

15-21 nmol/min·mg

分子量

~115 kDa

NCBI登錄號

運輸包裝

dry ice

儲存溫度

−70°C

基因資訊

human ... EIF2AK3(9451)

外觀

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

準備報告

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

法律資訊

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Carsten Carlberg
Nutrigenomics null
Josef Neu
Gastroenterology and Nutrition null
H P Harding et al.
Molecular cell, 5(5), 897-904 (2000-07-06)
Malfolded proteins in the endoplasmic reticulum (ER) inhibit translation initiation. This response is believed to be mediated by increased phosphorylation of eukaryotic initiation factor 2alpha (eIF2alpha) and is hypothesized to reduce the work load imposed on the folding machinery during
Identification of common variants influencing risk of the tauopathy Progressive Supranuclear Palsy
Gunter U
Nature Genetics (2011)
Julie A Moreno et al.
Science translational medicine, 5(206), 206ra138-206ra138 (2013-10-11)
During prion disease, an increase in misfolded prion protein (PrP) generated by prion replication leads to sustained overactivation of the branch of the unfolded protein response (UPR) that controls the initiation of protein synthesis. This results in persistent repression of

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