生物源
human
重組細胞
expressed in E. coli
化驗
≥98% (HPLC)
≥98% (SDS-PAGE)
形狀
lyophilized
效力
20.0-30.0 ng/mL ED50
分子量
9.7 kDa
包裝
pkg of 20 μg
技術
cell culture | mammalian: suitable
雜質
<0.1 EU/μg endotoxin, tested
顏色
white to off-white
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
human ... NRN1(51299)
相關類別
一般說明
NRN1 (neuritin 1) is a highly conserved extracellular GPI (glycosylphosphatidylinositol)-anchored protein that was initially identified in rat hippocampal dentate gyrus in a screening of candidate kainic acid-induced plasticity related genes. This protein is also secreted in a soluble form.
Recombinant human Neuritin is a covalently disulfide-linked homodimer, consisting of two 9.8kDa polypeptide monomers, each containing 89 amino acid residues.
Recombinant human Neuritin is a covalently disulfide-linked homodimer, consisting of two 9.8kDa polypeptide monomers, each containing 89 amino acid residues.
生化/生理作用
NRN1 (neuritin 1) is implicated in synaptic plasticity during brain development, and is an activity-dependent protein. Synaptic plasticity is dependent upon neuronal migration, and a study shows that NRN1 protein facilitates neuronal cell migration, and its levels influence microtubule stability. This protein also promotes dendritic arborization and synapse maturation in the central nervous system (CNS). It facilitates the survival of neural progenitors and differentiated neurons during early embryonic development, and during late development it is responsible for the maturation and formation of synapses by promoting the growth and stabilization of axons and dendrites. Study in human microendothelial cells (HMEC-1) shows that the expression of this protein is hypoxia-induced, and it is a hypoxic perinecrotic marker.
Recombinant human Neuritin is a covalently disulfide-linked homodimer, consisting of two 9.8kDa polypeptide monomers, each containing 89 amino acid residues.
Recombinant human Neuritin is a covalently disulfide-linked homodimer, consisting of two 9.8kDa polypeptide monomers, each containing 89 amino acid residues.
序列
MAGKCDAVFK GFSDCLLKLG DSMANYPQGL DDKTNIKTVC TYWEDFHSCT VTALTDCQEG AKDMWDKLRK ESKNLNIQGS LFELCGSGN
外觀
Lyophilized with no additives.
重構
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
Neuritin 1 promotes retinal ganglion cell survival and axonal regeneration following optic nerve crush.
Sharma TP et al
Cell Death & Disease, 6, e1661-e1661 (2015)
Neuritin 1 promotes neuronal migration.
Zito A et al
Brain Structure &Amp; Function, 219(1), 105-118 (2014)
Characterization of the expression of the hypoxia-induced genes neuritin, TXNIP and IGFBP3 in cancer.
Le Jan S et al
Febs Letters, 580(14), 3395-3400 (2006)
G S Naeve et al.
Proceedings of the National Academy of Sciences of the United States of America, 94(6), 2648-2653 (1997-03-18)
Neural activity and neurotrophins induce synaptic remodeling in part by altering gene expression. A cDNA encoding a glycosylphoshatidylinositol-anchored protein was identified by screening for hippocampal genes that are induced by neural activity. This molecule, named neuritin, is expressed in postmitotic-differentiating
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