SRP2119

RNA Polymerase II, RPB12 subunit, GST tagged human

recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

• 同義詞: ABC10-alpha, RPABC4, RPB10alpha, RPB12, RPB7.0, hRPB7.0, hsRPB10a
• 分類程式碼代碼: 12352202
• NACRES: NA.26

屬性

• 生物源: human
• 重組細胞: expressed in E. coli
• 化驗: ≥80% (SDS-PAGE)
• 形狀: frozen liquid
• 分子量: ~33 kDa
• 包裝: pkg of 10 μg
• 儲存條件: avoid repeated freeze/thaw cycles
• 濃度: 100 μg/mL
• 顏色: clear colorless
• NCBI登錄號: NM_005034
• UniProt登錄號: P53803
• 運輸包裝: dry ice
• 儲存溫度: −70°C
• 基因資訊: human ... POLR2K(5440)

描述

一般說明

POLR2K (RNA polymerase II subunit K) is located on human chromosome 8q22.[1] Rpb12 is the eukaryotic subunit that is also called as ABC10α. Rpb12 is the general subunit of all three eukaryotic RNA polymerases.[2]

生化／生理作用

RPB12 (also called RPB10 ) is shared between all three RNA polymerases and is homologous to the archaeal P subunit of RNA polymerase. Like RPB10, it is essential for yeast cell viability. RPB12 is also a zinc-binding protein with a canonical tetra-coordinating zinc motif but binds zinc in vitro much less efficiently than the RPB10 subunit. It has been shown to interact with both RPB1 and RPB2 in vitro and the human subunit can functionally substitute for its yeast counterpart.

RPB12/RPC10 (RNA polymerase II subunit K) is required for growth in Saccharomyces cerevisiae.[2] The carboxy-terminal domain (CTD) of RNAP II plays a major role in recruiting many of these activities to the transcriptional machinery.[3]

外觀

Clear and colorless frozen liquid solution

準備報告

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable