SML3761

BRD7586

≥98% (HPLC)

• 同義詞: 3-[(4-Chlorophenyl)sulfonyl]-N-[4-(4-pyridinyl)-2-thiazolyl]propanamide
• 經驗公式（希爾表示法）: C₁₇H₁₄ClN₃O₃S₂
• 分子量：: 407.89
• MDL號碼: MFCD07191127
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to beige
• 溶解度: DMSO: 2 mg/mL, clear
• 儲存溫度: -10 to -25°C
• SMILES 字串: [S](=O)(=O)(CCC(=O)Nc2[s]cc(n2)c3ccncc3)c1ccc(cc1)Cl
• InChI: 1S/C17H14ClN3O3S2/c18-13-1-3-14(4-2-13)26(23,24)10-7-16(22)21-17-20-15(11-25-17)12-5-8-19-9-6-12/h1-6,8-9,11H,7,10H2,(H,20,21,22)
• InChI 密鑰: MLSIIIMAQNQEOV-UHFFFAOYSA-N

描述

生化／生理作用

BRD7586 is a cell-permeable, and potent anti-CRISPR agent. BRD7586is a potent and selective inhibitor of SpCas9. It potently inhibits SpCas9 in both HEK293T and U2OS.eGFP.PEST cells without altering its expression, or induction of cytotoxicity. BRD7586 enhanced the specificity of SpCas9. BRD7586 inhibits genome editing at diverse endogenous loci. It is twofold more potent than BRD0539.

Cell-permeable, and potent anti-CRISPR agent; potent and selective inhibitor of SpCas9

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable