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Merck
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SML3736

Sigma-Aldrich

Hypoxia probe 2

95% (UPLC)

同義詞:

5’-Methoxy-1’,2’-dimethyl-3-(1-((3-oxo-3H-phenoxazin-7-yl)oxy)ethyl)-1H-indole-4’,7’-dione

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About This Item

經驗公式(希爾表示法):
C25H20N2O6
分子量::
444.44
分類程式碼代碼:
12352200
NACRES:
NA.77

品質等級

化驗

95% (UPLC)

形狀

powder

儲存條件

protect from light

顏色

, Faint orange to red

溶解度

DMSO: 2 mg/mL, clear (Warmed)

運輸包裝

wet ice

儲存溫度

-10 to -25°C

生化/生理作用

Hypoxia probe 2 is a resorufin-based non-fluorescent hypoxia probe that undergoes cytochrome P450 reductase (PH51)-catalyzed reduction to yield the fluorescent reporter resorufin (ex 545 nm, em 582 nm) in conditions of 4% O2 and lower, allowing imaging hypoxia levels similar to those detected by pimonidazole without the use of antibodies. When employed together with Tokyo green-based hypoxia probe 4 (Tokyo green ex 480 nm, em 515 nm), the probe pair allows the simultaneous (two-color) imaging of different hypoxia levels in living cells.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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Two Color Imaging of Different Hypoxia Levels in Cancer Cells.
Journal of the American Chemical Society, 145(4), 2572-2583 (2023)

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