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來源證明/COA

SML3203

Tebipenem

Name: Tebipenem
Brand: SIGMA

≥98% (HPLC)

同義詞:

(1R,5S,6S)-2-[1-(1,3-Thiazolin-2-yl)azetidin-3-yl]thio-6-[(R)-1-hydroxyeth yl]-1-methyl-carbapen-2-em-3-carboxylic acid, (4R,5S,6S)-3-[[1-(4,5-Dihydro-2-thiazolyl)-3-azetidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, L-084 active drug, LJC 11,036, LJC 11036, ME1211 active drug, SPR 859, SPR 994 active drug, SPR-859, SPR-994 active drug, SPR859, SPR994 active drug, TBM, TBM-PI active drug, Tebi-pivoxil active drug, [4R-[4α,5β,6β(R*)]]-3-[[1-(4,5-Dihydro-2-thiazolyl)-3-azetidinyl]thio]-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid

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About This Item

經驗公式（希爾表示法）:

C₁₆H₂₁N₃O₄S₂

CAS號碼:

161715-21-5

分子量：:

383.49

MDL號碼:

MFCD00936545

分類程式碼代碼:

51111800

NACRES:

NA.77

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Sigma-Aldrich

SML2846

Tebipenem pivoxil

Sigma-Aldrich

PZ0042

Sulopenem

Sigma-Aldrich

S9701

舒巴坦酸

Sigma-Aldrich

N2630

烟酰胺1，N⁶-乙烯基腺嘌呤二核苷酸

Sigma-Aldrich

C4520

头孢菌素钠盐

Sigma-Aldrich

C3416

羧苄青霉素二钠盐

Sigma-Aldrich

F8791

5-Fluoro-5′-deoxyuridine

Sigma-Aldrich

R3501

利福平

Sigma-Aldrich

N0632

β-烟酰胺腺嘌呤二核苷酸钠盐

Sigma-Aldrich

N0636

烟酰胺

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 2 mg/mL, clear

儲存溫度

−20°C

SMILES 字串

S1CCN=C1N2CC(C2)SC3=C(N4[C@H]([C@H]3C)[C@H](C4=O)[C@H](O)C)C(=O)O

InChI

1S/C16H21N3O4S2/c1-7-11-10(8(2)20)14(21)19(11)12(15(22)23)13(7)25-9-5-18(6-9)16-17-3-4-24-16/h7-11,20H,3-6H2,1-2H3,(H,22,23)/t7-,8-,10-,11-/m1/s1

InChI 密鑰

GXXLUDOKHXEFBQ-YJFSRANCSA-N

生化／生理作用

Carbapenem class broad-spectrum β-lactam antibiotic, active metabolite of Tebipenem pivoxil (L-084I; SPR994; Tebi-pivoxil; TBM-P).

Tebipenem (LJC 11,036; SPR859; TBM) is a carbapenem class broad-spectrum β-lactam antibiotic against both gram-positive and gram-negative bacteria, including penicillin-resistant S. pneumoniae (PRSP) and many β-lactamase-producing strains (respective MIC ≤6-200 and ≤25-390 ng/mL), while being less effective against methicillin-resistant S. aureus (MRSA), S. marcescens, and P. aeruginosa (respective MIC ranges 0.2 to12.5, 0.05 to100, 3.13 to >100 μg/mL). TBM is 2- to 64-fold more potent than imipenem, cefdinir, and faropenem against clinical isolates from respiratory and urinary-tract infections.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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分析證明 (COA)

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In vitro and in vivo activity of tebipenem against ESBL-producing E. coli.

Visanu Thamlikitkul et al.

Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 97(12), 1259-1268 (2015-03-15)

To determine in vitro and in vivo activity of tebipenem against ESBL-producing E. coli. Minimum inhibitory concentration (MIC) of tebipenem against 100 clinical isolates of ESBL-producing E. coli was performed by broth micro-dilution technique. Blood and urine samples from 10

Antibacterial Properties of Tebipenem Pivoxil Tablet, a New Oral Carbapenem Preparation against a Variety of Pathogenic Bacteria in Vitro and in Vivo.

Qi Yao et al.

Molecules (Basel, Switzerland), 21(1), 62-62 (2016-01-12)

To systemically investigate the in vitro and in vivo antibacterial properties of tebipenem pivoxil tablet. In addition, acute toxicity of this preparation was also studied. In vitro, minimum inhibitory concentration (MIC) or minimal inhibitory concentration (MBC) were determined by using

In vitro antibacterial activity of LJC 11,036, an active metabolite of L-084, a new oral carbapenem antibiotic with potent antipneumococcal activity.

M Hikida et al.

Antimicrobial agents and chemotherapy, 43(8), 2010-2016 (1999-08-03)

LJC 11,036 is the active metabolite of L-084, a novel oral carbapenem that exhibits potent broad-spectrum activity. Antibacterial activities of LJC 11,036 against clinical isolates from respiratory infections, such as Streptococcus pneumoniae (n = 52), Streptococcus pyogenes (n = 19)

Characterization of SPR994, an Orally Available Carbapenem, with Activity Comparable to Intravenously Administered Carbapenems.

Aileen Rubio et al.

ACS infectious diseases, 4(10), 1436-1438 (2018-08-18)

Carbapenems are potent antibacterials with broad-spectrum activity. However, poor oral absorption generally confines this important drug class to in-hospital use by intravenous (IV) administration. The continued rise in drug resistant pathogens creates a need for alternative oral therapies with broad-spectrum

Novel carbapenem antibiotics for parenteral and oral applications: in vitro and in vivo activities of 2-aryl carbapenems and their pharmacokinetics in laboratory animals.

Koichi Fujimoto et al.

Antimicrobial agents and chemotherapy, 57(2), 697-707 (2012-11-14)

SM-295291 and SM-369926 are new parenteral 2-aryl carbapenems with strong activity against major causative pathogens of community-acquired infections such as methicillin-susceptible Staphylococcus aureus, Streptococcus pneumoniae (including penicillin-resistant strains), Streptococcus pyogenes, Enterococcus faecalis, Klebsiella pneumoniae, Moraxella catarrhalis, Haemophilus influenzae (including β-lactamase-negative

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重要文件

Tebipenem

≥98% (HPLC)

About This Item

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屬性

品質等級

化驗

形狀

顏色

溶解度

儲存溫度

SMILES 字串

InChI

InChI 密鑰

描述

生化／生理作用

安全資訊

儲存類別代碼

水污染物質分類（WGK）

閃點（°F）

閃點（°C）

文件

分析證明 (COA)

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