SML2951

SGC-CK2-1

≥98% (HPLC)

• 同義詞: N-(5-(3-Cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-ylamino)-2-methylphenyl)propionamide
• 經驗公式（希爾表示法）: C₂₀H₂₁N₇O
• CAS號碼: 2470424-39-4
• 分子量：: 375.43
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to beige
• 溶解度: DMSO: 2 mg/mL, clear
• 儲存溫度: 2-8°C

描述

生化／生理作用

SGC-CK2-1 is a potent and highly selective casein 2 (CK2, CKII) inhibitor (CK2α/CK2α′ IC₅₀ = 4.2/2.3 nM by cell-free enzyme assay; DYRK2 IC₅₀ = 440 nM, IC₅₀≥3.4 μM against 465 other kinases). Unlike less specific CK2 inhibitors, SGC-CK2-1 shows no antiproliferation activity in HCT116 or U-87 MG cancer cultures (up to 10 μM) despite its potent cellular activity (CK2α/CK2α′ IC₅₀ = 36/16 nM by cellular NanoBRET assay).

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable