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Merck
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重要文件

SML2764

Sigma-Aldrich

Pitofenone hydrochloride

≥98% (HPLC)

同義詞:

2-[4-[2-(1-Piperidinyl)ethoxy]benzoyl]-benzoic acid methyl ester hydrochloride, Algifen Neo

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About This Item

經驗公式(希爾表示法):
C22H25NO4 · HCl
CAS號碼:
分子量::
403.90
MDL號碼:
分類程式碼代碼:
12352200
NACRES:
NA.77
暫時無法取得訂價和供貨情況

品質等級

化驗

≥98% (HPLC)

形狀

powder

儲存條件

desiccated

顏色

white to beige

溶解度

H2O: 2 mg/mL, clear

儲存溫度

−20°C

SMILES 字串

[Cl-].N3(CCCCC3)CCOc1ccc(cc1)C(=O)c2c(cccc2)C(=O)OC.[H+]

InChI

1S/C22H25NO4.ClH/c1-26-22(25)20-8-4-3-7-19(20)21(24)17-9-11-18(12-10-17)27-16-15-23-13-5-2-6-14-23;/h3-4,7-12H,2,5-6,13-16H2,1H3;1H

InChI 密鑰

ZRFIFDFEDPJBII-UHFFFAOYSA-N

生化/生理作用

Pitofenone is a potent muscarinic receptor antagonist. Pitofenone in combination with diclofenac exhibits potent antispasmodic effect in cholinergic spasm.
potent muscarinic receptor antagonist

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析證明 (COA)

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J Sanahuja et al.
DICP : the annals of pharmacotherapy, 24(4), 361-364 (1990-04-01)
A comparative, randomized, double-blind study of diclofenac sodium 75 mg im versus Baralgin (a combination drug composed of dipyrone and two spasmolytics) 5 mL iv was performed on 57 patients with renal colic. Both groups were comparable as to age
Shrinivas K Kulkarni et al.
Indian journal of experimental biology, 42(6), 567-569 (2004-07-21)
Biliary, ureteric and intestinal colic are extremely common clinical conditions associated with smooth muscle spasm. In the present study, antispasmodic activity was carried out against acetylcholine (10-640 ng/ml)-induced contractions on guinea pig ileum. Acetylcholine (10-640 ng/ml) induced concentration-dependent contraction of
K V Marthak et al.
Current medical research and opinion, 12(6), 366-373 (1991-01-01)
A single-blind, randomized clinical trial was carried out to compare the analgesic effectiveness in patients with renal colic of single intramuscular doses of diclofenac sodium (75 mg) versus a dipyrone (1 g)/spasmolytics combination, and diclofenac sodium (75 mg) versus pethidine

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