SML2760

SGC6870

≥98% (HPLC)

• 同義詞: (R)-4-(5-Bromothiophene-2-carbonyl)-5-(3,5-dimethylphenyl)-7-methyl-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one
• 經驗公式（希爾表示法）: C₂₃H₂₁BrN₂O₂S
• 分子量：: 469.39
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 光學活性: [α]/D +260 to +300°, c = 0.5 in methanol
• 顏色: white to beige
• 溶解度: DMSO: 2 mg/mL, clear
• 儲存溫度: 2-8°C

描述

生化／生理作用

Potent and selective protein arginine methyltransferase PRMT6 inhibitor.

SGC6870 is a potent and selective protein arginine methyltransferase PRMT6 inhibitor (IC₅₀ = 77 nM by cell-free assays; IC₅₀ = 0.8 μM against asymmetric H3R2 dimethylation of overexpressed PRMT6 in HEK293T cells) over all other PRMTs and 23 methyltransferases. The (S)-enantiomer SGC6870N is inactive toward PRMT6 and serves as an excellent control compound.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3