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SML2461

LM22B-10

Name: LM22B-10
Brand: SIGMA

≥98% (HPLC)

同義詞:

2,2′,2′′,2′′′-[[(4-Chlorophenyl)methylene]bis(4,1-phenylenenitrilo)]tetrakis[ethanol], 2,2′,2′,2′′′-[[(4-Chlorophenyl)methylene]bis(4,1-phenylenenitrilo)]tetrakisethanol

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About This Item

經驗公式（希爾表示法）:

C₂₇H₃₃ClN₂O₄

CAS號碼:

342777-54-2

分子量：:

485.01

MDL號碼:

MFCD00483554

分類程式碼代碼:

12352200

NACRES:

NA.77

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SCP0180

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化驗

≥98% (HPLC)

形狀

powder

顏色

faint blue to green

溶解度

DMSO: 2 mg/mL, clear

儲存溫度

−20°C

SMILES 字串

ClC1=CC=C(C(C2=CC=C(N(CCO)CCO)C=C2)C3=CC=C(N(CCO)CCO)C=C3)C=C1

InChI 密鑰

QCXQLSGBOUUVNH-UHFFFAOYSA-N

生化／生理作用

LM22B-10 is a brain penetrant, potent and selective TrkB and TrkC neurotrophin receptors agonist that improves cell survival and potently accelerated neurite outgrowth. LM22B-10 inhibits binding of BDNF to TrkB-expressing cells and NT-3 to TrkC-expressing cells.

brain penetrant, potent and selective TrkB and TrkC agonist

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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分析證明 (COA)

Lot/Batch Number

0000064483

0000064484

0000058263

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Regulating effect of glycyrrhetinic acid on bronchial asthma smooth muscle proliferation and apoptosis as well as inflammatory factor expression through ERK1/2 signaling pathway.

Tao Zhang et al.

Asian Pacific journal of tropical medicine, 10(12), 1172-1176 (2017-12-23)

To study the influence of glycyrrhetinic acid (GA) on bronchial asthma (BA) smooth muscle proliferation and apoptosis as well as inflammatory factor expression and its molecular mechanism. Male SD guinea pigs were selected and made into asthma models, bronchial asthma

A small molecule TrkB/TrkC neurotrophin receptor co-activator with distinctive effects on neuronal survival and process outgrowth.

Tao Yang et al.

Neuropharmacology, 110(Pt A), 343-361 (2016-06-24)

Neurotrophin (NT) receptors are coupled to numerous signaling networks that play critical roles in neuronal survival and plasticity. Several non-peptide small molecule ligands have recently been reported that bind to and activate specific tropomyosin-receptor kinase (Trk) NT receptors, stimulate their

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重要文件

LM22B-10

≥98% (HPLC)

About This Item

推薦產品

屬性

化驗

形狀

顏色

溶解度

儲存溫度

SMILES 字串

InChI 密鑰

描述

生化／生理作用

安全資訊

儲存類別代碼

水污染物質分類（WGK）

閃點（°F）

閃點（°C）

文件

分析證明 (COA)

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