SML2408

UNC3866 trifluoroacetate salt

≥98% (HPLC)

• 同義詞: N-[4-(1,1-Dimethylethyl)benzoyl]-L-phenylalanyl-L-alanyl-L-leucyl-N6,N6-diethyl-L-lysyl-L-Serine methyl ester trifluoroacetate
• 經驗公式（希爾表示法）: C₄₃H₆₆N₆O₈
• 分子量：: 795.02
• 分類程式碼代碼: 12352200

屬性

• 化驗: ≥98% (HPLC)
• 形狀: lyophilized powder (white)
• 顏色: white to off-white
• 運輸包裝: wet ice
• 儲存溫度: −20°C

描述

生化／生理作用

Antagonist of chromodomains CBX4/7 of Polycomb repressive complex 1

UNC3866 inhibits the CBX chromodomains of the Polycomb repressive complex 1 (PRC1), which is involved in transcriptional repression. UNC3866 selectively targets CBX4 and CBX7 most potently, with Kd values of ∼100 nM. The PRC1 chromodomains facilitate PRC1-mediated transcriptional repression by targeting the complex to Trimethyllysine 27 on histone 3 (H3K27me3). UNC3866 antagonizes the methyllysine (Kme) reading function, and has been shown to inhibit the PC3 prostate cancer cell proliferation associated with CBX7 overexpression.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable