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Merck
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文件

SML2063

Sigma-Aldrich

Davunetide trifluoroacetate salt

≥95% (HPLC)

同義詞:

AL-108, Asn-Ala-Pro-Val-Ser-Ile-Pro-Gln, L-Asparaginyl-L-alanyl-L-prolyl-L-valyl-L-seryl-L-isoleucyl-L-prolyl-L-Glutamine, NAP, NAP peptide, NAPVSIPQ

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About This Item

經驗公式（希爾表示法）:
C36H60N10O12 · xC2HF3O2
CAS號碼:
211439-12-2
分子量：:
824.92 (free base basis)
分類程式碼代碼:
12352200
NACRES:
NA.77

化驗

≥95% (HPLC)

形狀

powder

成份

Peptide content, ≥60%

顏色

white to beige

運輸包裝

wet ice

儲存溫度

−20°C

InChI

1S/C36H60N10O12/c1-6-18(4)28(35(56)46-14-8-9-23(46)31(52)41-21(36(57)58)11-12-25(38)48)44-30(51)22(16-47)42-33(54)27(17(2)3)43-32(53)24-10-7-13-45(24)34(55)19(5)40-29(50)20(37)15-26(39)49/h17-24,27-28,47H,6-16,37H2,1-5H3,(H2,38,48)(H2,39,49)(H,40,50)(H,41,52)(H,42,54)(H,43,53)(H,44,51)(H,57,58)/t18-,19-,20-,21-,22-,23-,24-,27-,28-/m0/s1

InChI 密鑰

DWLTUUXCVGVRAV-XWRHUKJGSA-N

生化／生理作用

Davunetide (NAPVSIPQ; NAP) is an eight amino acid peptide identified as the active component of activity-dependent neuroprotective protein (ADNP). It has been found to be neuro-protective at femtomolar concentrations in vitro against the neural toxicity of a wide range of compounds. Davunetide has been investigated for Parkinson′s disease and schizophrenia and in clinical trials for Alzheimner′s Disease, targeting microtubule-tau Interaction.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析證明 (COA)

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Agata Grazia D'Amico et al.
Journal of molecular neuroscience : MN, 61(2), 256-266 (2016-12-03)
The retinal microvascular damage is a complication of diabetic retinopathy (DR). Hyperglycemia and hypoxia are responsible of aberrant vessel's proliferation. The cellular response to hypoxia is mediated through activation of hypoxia-inducible factors (HIFs). Among these, HIF-1α modulates expression of its
Jun Zhang et al.
Physiology & behavior, 174, 67-73 (2017-03-05)
Memory loss and cognition decline are the main clinical manifestations of Alzheimer's disease (AD). Amyloid β protein (Aβ) aggregated in the brain is one of the key pathological characteristics of AD and responsible for the deficits in learning and memory.
T Q Melo et al.
Experimental brain research, 235(3), 731-742 (2016-11-21)
The formation of oligomers and aggregates of overexpressed or mutant α-synuclein play a role in the degeneration of dopaminergic neurons in Parkinson's disease by causing dysfunction of mitochondria, reflected in their disturbed mobility and production of ROS. The mode of

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