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Merck
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重要文件

SML1682

Sigma-Aldrich

CDN1163

≥98% (HPLC)

同義詞:

4-(1-甲基乙氧基)-N-(2-甲基-8-喹啉基)-苯甲酰胺

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About This Item

經驗公式(希爾表示法):
C20H20N2O2
CAS號碼:
分子量::
320.39
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
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品質等級

化驗

≥98% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 5 mg/mL, clear (warmed)

儲存溫度

2-8°C

SMILES 字串

CC1=NC2=C(NC(C3=CC=C(OC(C)C)C=C3)=O)C=CC=C2C=C1

InChI

1S/C20H20N2O2/c1-13(2)24-17-11-9-16(10-12-17)20(23)22-18-6-4-5-15-8-7-14(3)21-19(15)18/h4-13H,1-3H3,(H,22,23)

InChI 密鑰

GVGVYDCVFBGALZ-UHFFFAOYSA-N

生化/生理作用

CDN1163处理可降低与糖异生和脂肪生成有关的基因的肝表达,同时减弱内质网(ER)应激反应和ER应激诱导的细胞凋亡。[1]CDN1163可与肌膜/内质网Ca2+-ATPase(SERCA)发生相互作用,并增强ER Ca2+的内含量。[2]
CDN1163是肌/内质网Ca2+-ATPase(SERCA)的一种变构激活剂。
CDN1163是肌/内质网Ca2+-ATPase(SERCA)的一种变构激活剂,可有效降低ob/ob小鼠的空腹血糖,改善的葡萄糖耐量和肝脂肪变性。另外,CDN1163可诱导肥胖组织重量显著减少,而对ob/ob小鼠的瘦体重没有影响。CDN1163对瘦对照小鼠的葡萄糖水平或体重没有影响。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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