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SML1284

Sigma-Aldrich

Efavirenz Ready Made Solution

10 mg/mL in DMSO

同義詞:

(4S)-6-Chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-2,4-dihydro-1H-3,1-benzoxazin-2-one, (4S)-6-Chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one

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About This Item

經驗公式(希爾表示法):
C14H9ClF3NO2
CAS號碼:
分子量::
315.67
分類程式碼代碼:
12352200
NACRES:
NA.77

形狀

DMSO solution

品質等級

濃度

10 mg/mL in DMSO

運輸包裝

dry ice

儲存溫度

−20°C

InChI

1S/C14H9ClF3NO2/c15-9-3-4-11-10(7-9)13(14(16,17)18,21-12(20)19-11)6-5-8-1-2-8/h3-4,7-8H,1-2H2,(H,19,20)/t13-/m0/s1

InChI 密鑰

XPOQHMRABVBWPR-ZDUSSCGKSA-N

生化/生理作用

Efavirenz is a nonnucleoside reverse transcriptase inhibitor (NNRTI). Efavirenz is an anti-HIV drug, commonly used in combination therapy for AIDs treatment. Efavirenz is part of highly active antiretroviral therapy (HAART) for the treatment of a human immunodeficiency virus (HIV) type 1.
The plasma levels of this drug can determine the failure of treatment and CNS (central nervous system) side-effects in patients infected with HIV (human immunodeficiency virus).

象形圖

Health hazardEnvironment

訊號詞

Danger

危險聲明

危險分類

Aquatic Chronic 2 - Repr. 1B

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

閃點(°F)

188.6 °F

閃點(°C)

87 °C


分析證明 (COA)

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C Marzolini et al.
AIDS (London, England), 15(1), 71-75 (2001-02-24)
Limited information exists on the clinical usefulness of drug level monitoring for efavirenz, a once-daily non-nucleoside reverse transcriptase inhibitor (NNRTI). The aim of this study was to determine whether efavirenz plasma concentration monitoring could predict treatment failure and central nervous

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