SML1188

PYZD-4409

≥98% (HPLC)

• 同義詞: 1-(3-Chloro-4-fluorophenyl)-4-[(5-nitro-2-furanyl)methylene]-3,5-pyrazolidinedione
• 經驗公式（希爾表示法）: C₁₄H₇ClFN₃O₅
• CAS號碼: 423148-78-1
• 分子量：: 351.67
• MDL號碼: MFCD01828668
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329825708
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: , white to very dark brown
• 溶解度: DMSO: 10 mg/mL, clear
• 儲存溫度: −20°C
• SMILES 字串: FC1=CC=C(N2C(C(C(N2)=O)=CC3=CC=C([N+]([O-])=O)O3)=O)C=C1Cl
• InChI: 1S/C14H7ClFN3O5/c15-10-5-7(1-3-11(10)16)18-14(21)9(13(20)17-18)6-8-2-4-12(24-8)19(22)23/h1-6H,(H,17,20)
• InChI 密鑰: MSYMKEYWUWVZQY-UHFFFAOYSA-N

描述

生化／生理作用

PYZD-4409 inhibts ATP-dependent activation of human ubiquitin activating enzyme E1 with an IC₅₀ of 20 mM. PYZD-4409 induces cell death, and inhbits clonogenic growth of leukemia and myeloma cell lines, and inhibits leukemia xenograft tumor growth in mice.

安全資訊

• 象形圖: GHS06
• 訊號詞: Danger
• 危險聲明: H301,H315,H319,H335
• 防範說明: P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
• 危險分類: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable