推薦產品
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 20 mg/mL, clear
起源
GlaxoSmithKline
相關疾病
cancer
儲存溫度
2-8°C
SMILES 字串
[n]2(c3c([nH][c]2=O)cnc4c3cc(c(c4)c5c(n[o]c5C)C)OC)[C@H](C)c1ncccc1
InChI
1S/C23H21N5O3/c1-12-21(14(3)31-27-12)16-9-18-15(10-20(16)30-4)22-19(11-25-18)26-23(29)28(22)13(2)17-7-5-6-8-24-17/h5-11,13H,1-4H3,(H,26,29)/t13-/m1/s1
InChI 密鑰
VUVUVNZRUGEAHB-CYBMUJFWSA-N
應用
GSK1210151A 或 I-BET151 已用于研究其在治疗 MLL（混合谱系白血病）-融合性白血病中对 BET（溴结构域和额外末端）募集染色质的抑制作用。[1]
生化／生理作用
GSK1210151A（I-BET151）是 BET（溴结构域和额外末端域蛋白）家族的乙酰赖氨酸识别染色质 ′ 衔接子 ′ 蛋白抑制剂。
GSK1210151A（I-BET151）是 BET（溴结构域和额外末端域蛋白）家族的乙酰赖氨酸识别染色质 ′衔接子′ 蛋白抑制剂。GSK1210151A 取代了染色质的 BRD3 和 BRD4、PAFc 和 SEC 组份，从而抑制了参与混合谱系白血病（MLL）的关键基因（BCL2、C-MYC 和 CDK6）的转录。GSK1210151A（I-BET151）在 2 个 MLL 动物模型中显示出良好的疗效。
其他說明
化学探针门户网站已对 GSK1210151A 进行了专家评审和推荐。欲了解更多信息，请访问化学探针门户网站上的 GSK1210151A 探针摘要 。
訊號詞
Danger
危險聲明
危險分類
Acute Tox. 3 Oral
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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分析證明 (COA)
Lot/Batch Number
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