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Merck
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重要文件

SML0506

Sigma-Aldrich

LY-411575

≥97% (HPLC)

同義詞:

LSN-411575, LY 411575, N2-[(2S)-2-(3,5-二氟苯基)-2-羟基乙酰]-N1-[(7S)-5-甲基-6-氧代-6,7-二氢-5H-二苯并[b,d]氮杂-7-基]-L-丙氨酰胺

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About This Item

經驗公式(希爾表示法):
C26H23F2N3O4
CAS號碼:
分子量::
479.48
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
暫時無法取得訂價和供貨情況

化驗

≥97% (HPLC)

形狀

powder

顏色

white to beige

溶解度

DMSO: 5 mg/mL, clear

運輸包裝

wet ice

儲存溫度

−20°C

SMILES 字串

C[C@H](NC(=O)[C@@H](O)c1cc(F)cc(F)c1)C(=O)N[C@@H]2C(=O)N(C)c3ccccc3-c4ccccc24

InChI

1S/C26H23F2N3O4/c1-14(29-25(34)23(32)15-11-16(27)13-17(28)12-15)24(33)30-22-20-9-4-3-7-18(20)19-8-5-6-10-21(19)31(2)26(22)35/h3-14,22-23,32H,1-2H3,(H,29,34)(H,30,33)/t14-,22-,23-/m0/s1

InChI 密鑰

ULSSJYNJIZWPSB-CVRXJBIPSA-N

相關類別

應用

LY-411575已被用作有效的γ-分泌酶抑制剂和Notch抑制剂。[1][2][3]

生化/生理作用

LY-411575是一种有效的细胞渗透性和选择性 γ-分泌酶抑制剂,可在急性或慢性治疗后降低 Aβ40/42,并阻断Notch活化。
LY-411575是一种有效的细胞渗透性和选择性γ-分泌酶抑制剂,可在急性或慢性治疗后降低Aβ/42,并阻断Notch活化。研究(癌细胞)已显示用LSN-411575治疗可通过抑制HES1表达和ERK磷酸化,阻滞KrasG12V驱动的NSCLC。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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K Pandya et al.
British journal of cancer, 105(6), 796-806 (2011-08-19)
We reported that Notch-1, a potent breast oncogene, is activated in response to trastuzumab and contributes to trastuzumab resistance in vitro. We sought to determine the preclinical benefit of combining a Notch inhibitor (γ-secretase inhibitor (GSI)) and trastuzumab in both
Enzymatic assays for studying intramembrane proteolysis.
Bolduc D M, et al.
Methods in Enzymology, 584, 295-308 (2017)
Prion-protein-interacting amyloid-β oligomers of high molecular weight are tightly correlated with memory impairment in multiple Alzheimer mouse models.
Kostylev M A, et al.
The Journal of Biological Chemistry, 290(28), 17415-17438 (2015)
Different developmental histories of beta-cells generate functional and proliferative heterogeneity during islet growth.
Singh S P, et al.
Nature Communications, 8(1), 664-664 (2017)
Julia Freudenblum et al.
Frontiers in cell and developmental biology, 8, 586651-586651 (2020-10-27)
Pancreatic islets, discrete microorgans embedded within the exocrine pancreas, contain beta cells which are critical for glucose homeostasis. Loss or dysfunction of beta cells leads to diabetes, a disease with expanding global prevalence, and for which regenerative therapies are actively

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